确定基因组复制所需的流感病毒蛋白。
Determination of influenza virus proteins required for genome replication.
作者信息
Huang T S, Palese P, Krystal M
机构信息
Department of Microbiology, Mt. Sinai School of Medicine, New York, New York 10029-6574.
出版信息
J Virol. 1990 Nov;64(11):5669-73. doi: 10.1128/JVI.64.11.5669-5673.1990.
Abstract
An artificial vaccinia virus vector-driven replication system for influenza virus RNA has been developed. In this system, a synthetic NS-like gene is replicated and expressed by influenza virus proteins supplied through infection with vaccinia virus recombinant vectors. The minimum subset of influenza virus proteins needed for specific replication and expression of the viral ribonucleoprotein was found to be the three polymerase proteins (PB1, PB2, and PA) and the nucleoprotein.
摘要
已开发出一种用于流感病毒RNA的人工痘苗病毒载体驱动复制系统。在该系统中，通过痘苗病毒重组载体感染提供的流感病毒蛋白可复制并表达一个合成的类NS基因。发现病毒核糖核蛋白特异性复制和表达所需的流感病毒蛋白的最小亚组为三种聚合酶蛋白（PB1、PB2和PA）和核蛋白。
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