Cummins D, McCormick J B, Bennett D, Samba J A, Farrar B, Machin S J, Fisher-Hoch S P
Department of Hematology, University College, London, England.
JAMA. 1990;264(16):2093-6.
A prospective audiometric evaluation of 69 hospitalized febrile patients in Sierra Leone, West Africa, revealed a sensorineural hearing deficit (SNHD) in 14 (29%) of 49 confirmed cases of Lassa fever and in 0 of 20 febrile controls. An SNHD was present in nine (17.6%) of 51 people who had evidence of previous Lassa virus infection. Twenty-six of 32 local residents who had previously sustained a sudden deafness had antibody titers to Lassa virus of 16 or greater, compared with six of 32 matched controls. Lassa fever is associated with an incidence of SNHD, which considerably exceeds that previously reported with any other postnatally acquired infection, and accounts for a prevalence of virus-related hearing impairment in the eastern province of Sierra Leone that is greater than that reported from anywhere else in the world.
对西非塞拉利昂69名住院发热患者进行的前瞻性听力测定评估显示，在49例确诊的拉沙热病例中，有14例（29%）出现感音神经性听力缺陷（SNHD），而20例发热对照病例中无一例出现该情况。在51名有既往拉沙病毒感染证据的人中，有9例（17.6%）出现SNHD。在32名既往突发耳聋的当地居民中，26人的拉沙病毒抗体滴度为16或更高，而32名匹配对照者中只有6人如此。拉沙热与SNHD的发生率相关，该发生率大大超过此前报道的任何其他后天获得性感染，并且在塞拉利昂东部省份造成了与病毒相关的听力障碍流行率高于世界其他任何地方所报道的情况。
