阿片受体μ1 与与 HIV 共病 binge-drinking 患者创伤后应激障碍相关诊断。
OPRM1 and diagnosis-related posttraumatic stress disorder in binge-drinking patients living with HIV.
机构信息
Division of Behavioral Genetics, Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.
出版信息
AIDS Behav. 2012 Nov;16(8):2171-80. doi: 10.1007/s10461-011-0095-8.
Abstract
Posttraumatic stress disorder (PTSD) has been linked to numerous negative outcomes in persons living with HIV (PLH) and there is evidence that PTSD symptoms may play a role in maintaining alcohol use problems. The opioid receptor mu-1 (OPRM1) gene may play a role in both PTSD and alcohol use. We examined the association between PTSD and drinking motives as well as variation in the OPRM1 as a predictor of both PTSD and drinking motives in a sample of 201 PLH reporting recent binge drinking. Self-reported PTSD symptom severity was significantly associated with drinking motives for coping, enhancement, and socialization. OPRM1 variation was associated with decreased PTSD symptom severity as well as enhancement motives for drinking.
摘要
创伤后应激障碍（PTSD）与 HIV 感染者（PLH）的许多负面后果有关，有证据表明 PTSD 症状可能在维持酒精使用问题方面发挥作用。阿片受体 mu-1（OPRM1）基因可能在 PTSD 和酒精使用中都起作用。我们在 201 名报告最近 binge drinking 的 PLH 样本中，检查了 PTSD 与饮酒动机之间的关联，以及 OPRM1 的变化作为 PTSD 和饮酒动机的预测因子。自我报告的 PTSD 症状严重程度与应对、增强和社交的饮酒动机显著相关。OPRM1 变异与 PTSD 症状严重程度降低以及饮酒的增强动机有关。
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