Hayashi H, Ozaki T, Yasuoka S, Ogura T
Third Department of Internal Medicine, School of Medicine, Tokushima University, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Apr;28(4):580-6.
We measured NCF activity and examined the characteristics of NCF in bronchoalveolar lavage (BAL) fluid, sputum and culture media of alveolar macrophages. Several kinds of NCF were detected in BAL fluid obtained from normal volunteers, and at least a part of these NCF was thought to be derived from alveolar macrophages. NCF activity, especially complement-derived NCF, was increased in BAL fluid and in sputum obtained from patients with chronic respiratory tract infection. In patients with idiopathic interstitial pneumonia, alveolar macrophage-derived NCF as well as complement derived NCF were increased in BAL fluid. These results indicate that different types of NCF may increase in response to the disease state or pathogenesis, and play important roles in neutrophil accumulation in the respiratory tract.
我们测量了中性粒细胞趋化因子（NCF）活性，并检测了支气管肺泡灌洗（BAL）液、痰液及肺泡巨噬细胞培养基中NCF的特性。在正常志愿者的BAL液中检测到了几种NCF，并且认为这些NCF中至少有一部分源自肺泡巨噬细胞。慢性呼吸道感染患者的BAL液和痰液中，NCF活性，尤其是补体衍生的NCF活性有所增加。在特发性间质性肺炎患者中，BAL液中肺泡巨噬细胞衍生的NCF以及补体衍生的NCF均增加。这些结果表明，不同类型的NCF可能会因疾病状态或发病机制而增加，并在呼吸道中性粒细胞积聚中发挥重要作用。
