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Predicting toxicity from radiation therapy--it's genetic, right?

作者信息

Kelsey Chris R, Rosenstein Barry S, Marks Lawrence B

出版信息

Cancer. 2012 Jul 15;118(14):3450-4. doi: 10.1002/cncr.26670. Epub 2011 Dec 5.

DOI:10.1002/cncr.26670
PMID:22144075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4287226/
Abstract
摘要

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本文引用的文献

1
Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy.非同源末端连接基因 LIG4 的遗传变异与接受根治性放疗的非小细胞肺癌患者的严重放射性肺炎。
Cancer. 2012 Jan 15;118(2):528-35. doi: 10.1002/cncr.26214. Epub 2011 Jun 29.
2
Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy.同源重组基因多态性与接受根治性放疗的非小细胞肺癌患者的临床结局
PLoS One. 2011;6(5):e20055. doi: 10.1371/journal.pone.0020055. Epub 2011 May 25.
3
A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint.一种 TGFβ1 基因启动子内的多态性与使用客观放射学终点的放射敏感性相关。
Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):e247-55. doi: 10.1016/j.ijrobp.2011.02.064. Epub 2011 May 24.
4
Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.碱基切除修复基因 XRCC1 和 APEX1 的功能多态性可预测接受根治性放疗的非小细胞肺癌患者放射性肺炎的风险。
Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):e67-73. doi: 10.1016/j.ijrobp.2010.11.079. Epub 2011 Mar 21.
5
Identification of SNPs associated with susceptibility for development of adverse reactions to radiotherapy.鉴定与放射治疗不良反应易感性相关的单核苷酸多态性。
Pharmacogenomics. 2011 Feb;12(2):267-75. doi: 10.2217/pgs.10.186.
6
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.全基因组关联研究鉴定与接受前列腺癌放射治疗后的非裔美国男性勃起功能障碍发展相关的单核苷酸多态性（SNPs）。
Int J Radiat Oncol Biol Phys. 2010 Dec 1;78(5):1292-300. doi: 10.1016/j.ijrobp.2010.07.036.
7
Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.炎症相关基因中的遗传变异与非小细胞肺癌治疗后辐射诱导的毒性有关。
PLoS One. 2010 Aug 25;5(8):e12402. doi: 10.1371/journal.pone.0012402.
8
Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy.P53 和 ATM 多态性与放疗肺癌患者放射性肺炎风险的相关性。
Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1402-7. doi: 10.1016/j.ijrobp.2009.12.042. Epub 2010 Aug 21.
9
Establishment of a Radiogenomics Consortium.放射基因组学联盟的建立。
Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1295-6. doi: 10.1016/j.ijrobp.2009.12.017.
10
ATM polymorphisms are associated with risk of radiation-induced pneumonitis.ATM 多态性与放射性肺炎的发病风险相关。
Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1360-8. doi: 10.1016/j.ijrobp.2009.07.1675. Epub 2010 Feb 18.