• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

纤溶酶原激活物抑制剂-1基因的遗传变异与肺癌患者放射性肺炎风险增加相关。

Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients.

作者信息

Liu Bo, Tang Yang, Yi Minxiao, Liu Qingxu, Xiong Huihua, Hu Guangyuan, Yuan Xianglin

机构信息

Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

出版信息

Cancer Med. 2017 Mar;6(3):681-688. doi: 10.1002/cam4.1011. Epub 2017 Feb 17.

DOI:10.1002/cam4.1011
PMID:28211612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5345627/
Abstract

Plasminogen activator inhibitor-1 (PAI-1) plays a crucial role in the process of lung injury, although its association with radiation pneumonitis (RP) is unclear. We hypothesized that genetic variants in PAI-1 may influence the risk of RP. In this study, 169 lung cancer patients were genotyped for six single-nucleotide polymorphisms in PAI-1 using the Sequenom MassARRAY system. The risk of RP was evaluated by Cox proportional hazards analyses. The cumulative RP probabilities by genotype were assessed using Kaplan-Meier analyses. Univariate and multivariate analyses revealed that PAI-1:rs7242 GT/GG was correlated with an increased occurrence of grade ≥3 RP (crude hazard ratio = 3.331; 95% confidence interval, 1.168-9.497; P = 0.024). Our results indicated that PAI-1:rs7242 in the 3'-untranslated region of PAI-1 can be a predictor of grade ≥3 RP before radiotherapy.

摘要

纤溶酶原激活物抑制剂-1（PAI-1）在肺损伤过程中起关键作用，尽管其与放射性肺炎（RP）的关联尚不清楚。我们推测PAI-1基因变异可能影响RP的风险。在本研究中，使用Sequenom MassARRAY系统对169例肺癌患者的PAI-1基因中的六个单核苷酸多态性进行基因分型。通过Cox比例风险分析评估RP风险。使用Kaplan-Meier分析评估按基因型分类的累积RP概率。单因素和多因素分析显示，PAI-1:rs7242 GT/GG与≥3级RP发生率增加相关（粗风险比 = 3.331；95%置信区间，1.168 - 9.497；P = 0.024）。我们的结果表明，PAI-1 3'非翻译区的PAI-1:rs7242可作为放疗前≥3级RP的预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5415/5345627/e907cc1d0a8d/CAM4-6-681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5415/5345627/e907cc1d0a8d/CAM4-6-681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5415/5345627/e907cc1d0a8d/CAM4-6-681-g001.jpg

相似文献

1
Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients.纤溶酶原激活物抑制剂-1基因的遗传变异与肺癌患者放射性肺炎风险增加相关。
Cancer Med. 2017 Mar;6(3):681-688. doi: 10.1002/cam4.1011. Epub 2017 Feb 17.
2
Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.LIN28B 基因的遗传变异可预测接受根治性放射治疗的非小细胞肺癌患者发生严重放射性肺炎。
Eur J Cancer. 2014 Jul;50(10):1706-1716. doi: 10.1016/j.ejca.2014.03.008. Epub 2014 Apr 26.
3
Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy.转化生长因子β1（TGFβ1）基因rs1982073处的单核苷酸多态性：T869C与接受根治性放疗的非小细胞肺癌患者发生放射性肺炎的风险相关。
J Clin Oncol. 2009 Jul 10;27(20):3370-8. doi: 10.1200/JCO.2008.20.6763. Epub 2009 Apr 20.
4
Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy.ATG16L2 潜在功能变异预测非小细胞肺癌患者根治性放疗后放射性肺炎及结局
J Thorac Oncol. 2018 May;13(5):660-675. doi: 10.1016/j.jtho.2018.01.028. Epub 2018 Feb 15.
5
A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy.APEX1基因DNA修复结构域的多态性与肺癌患者放疗后放射性肺炎的发生风险相关。
Br J Radiol. 2014 Aug;87(1040):20140093. doi: 10.1259/bjr.20140093. Epub 2014 Jun 2.
6
ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.ATM 多态性可预测接受根治性放疗的非小细胞肺癌患者发生严重放射性肺炎的风险。
Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1066-73. doi: 10.1016/j.ijrobp.2012.09.024. Epub 2012 Nov 12.
7
Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.碱基切除修复基因 XRCC1 和 APEX1 的功能多态性可预测接受根治性放疗的非小细胞肺癌患者放射性肺炎的风险。
Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):e67-73. doi: 10.1016/j.ijrobp.2010.11.079. Epub 2011 Mar 21.
8
Polymorphisms in BMP2/BMP4, with estimates of mean lung dose, predict radiation pneumonitis among patients receiving definitive radiotherapy for non-small cell lung cancer.骨形态发生蛋白2/骨形态发生蛋白4（BMP2/BMP4）的多态性以及平均肺剂量估计值，可预测接受非小细胞肺癌根治性放疗患者的放射性肺炎。
Oncotarget. 2017 Jun 27;8(26):43080-43090. doi: 10.18632/oncotarget.17904.
9
ATM polymorphisms are associated with risk of radiation-induced pneumonitis.ATM 多态性与放射性肺炎的发病风险相关。
Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1360-8. doi: 10.1016/j.ijrobp.2009.07.1675. Epub 2010 Feb 18.
10
Plasminogen activator inhibitor variants PAI-1 A15T and PAI-2 S413C influence lung cancer prognosis.纤溶酶原激活物抑制剂变体PAI-1 A15T和PAI-2 S413C影响肺癌预后。
Lung Cancer. 2009 Aug;65(2):237-41. doi: 10.1016/j.lungcan.2008.11.012. Epub 2008 Dec 31.

引用本文的文献

1
Association between Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort.韩国病例对照队列研究中多态性与缺血性脑卒中的关联。
Int J Mol Sci. 2023 Apr 28;24(9):8041. doi: 10.3390/ijms24098041.
2
Promising Biomarkers of Radiation-Induced Lung Injury: A Review.辐射诱导肺损伤的潜在生物标志物：综述
Biomedicines. 2021 Sep 8;9(9):1181. doi: 10.3390/biomedicines9091181.
3
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization.eNAMPT/TLR4 信号通路在放射性肺损伤中的作用：eNAMPT 中和的保护作用。

本文引用的文献

1
MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.基质金属蛋白酶-1启动子多态性与接受放疗的肺癌患者发生放射性肺损伤的风险相关。
Oncotarget. 2016 Oct 25;7(43):70175-70184. doi: 10.18632/oncotarget.12164.
2
Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model.截短型纤溶酶原激活物抑制剂-1蛋白在小鼠模型中可保护免受辐射介导的肺纤维化影响。
Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1163-72. doi: 10.1016/j.ijrobp.2015.11.044. Epub 2015 Dec 14.
3
Genetic variants in PI3K/AKT pathway are associated with severe radiation pneumonitis in lung cancer patients treated with radiation therapy.
Transl Res. 2022 Jan;239:44-57. doi: 10.1016/j.trsl.2021.06.002. Epub 2021 Jun 15.
4
Severity of radiation pneumonitis, from clinical, dosimetric and biological features: a pilot study.从临床、剂量学和生物学特征看放射性肺炎的严重程度：一项初步研究。
Radiat Oncol. 2020 Oct 27;15(1):246. doi: 10.1186/s13014-020-01694-1.
5
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy.HIPK2 基因变异对接受放疗的肺癌患者放射性肺炎风险的影响。
Radiat Oncol. 2020 Jan 8;15(1):9. doi: 10.1186/s13014-019-1456-0.
6
Validating the pivotal role of the immune system in low-dose radiation-induced tumor inhibition in Lewis lung cancer-bearing mice.验证免疫系统在低剂量辐射诱导的 Lewis 肺癌荷瘤小鼠肿瘤抑制中的关键作用。
Cancer Med. 2018 Apr;7(4):1338-1348. doi: 10.1002/cam4.1344. Epub 2018 Feb 25.
7
Association between plasminogen activator inhibitor gene polymorphisms and osteonecrosis of the femoral head susceptibility: A case-control study.纤溶酶原激活物抑制剂基因多态性与股骨头坏死易感性的关联：一项病例对照研究。
Medicine (Baltimore). 2017 Oct;96(42):e7047. doi: 10.1097/MD.0000000000007047.
PI3K/AKT信号通路中的基因变异与接受放射治疗的肺癌患者严重放射性肺炎相关。
Cancer Med. 2016 Jan;5(1):24-32. doi: 10.1002/cam4.564. Epub 2015 Dec 8.
4
Genetic variants in the ITGB6 gene is associated with the risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy.整合素β6（ITGB6）基因的遗传变异与接受胸部放射治疗的肺癌患者发生放射性肺炎的风险相关。
Tumour Biol. 2016 Mar;37(3):3469-77. doi: 10.1007/s13277-015-4171-y. Epub 2015 Oct 8.
5
Nondosimetric risk factors for radiation-induced lung toxicity.辐射诱导肺毒性的非剂量学风险因素。
Semin Radiat Oncol. 2015 Apr;25(2):100-9. doi: 10.1016/j.semradonc.2014.12.003. Epub 2014 Dec 15.
6
SKI2162, an inhibitor of the TGF-β type I receptor (ALK5), inhibits radiation-induced fibrosis in mice.SKI2162，一种转化生长因子-β I 型受体（ALK5）抑制剂，可抑制小鼠的辐射诱导纤维化。
Oncotarget. 2015 Feb 28;6(6):4171-9. doi: 10.18632/oncotarget.2878.
7
Association of the plasminogen activator inhibitor-1 (PAI-1) Gene -675 4G/5G and -844 A/G promoter polymorphism with risk of keloid in a Chinese Han population.纤溶酶原激活物抑制剂-1（PAI-1）基因-675 4G/5G和-844 A/G启动子多态性与中国汉族人群瘢痕疙瘩风险的相关性
Med Sci Monit. 2014 Oct 28;20:2069-73. doi: 10.12659/MSM.892397.
8
Lung cancer: thoracic radiotherapy improves survival in small-cell lung cancer.肺癌：胸部放疗可提高小细胞肺癌的生存率。
Nat Rev Clin Oncol. 2014 Nov;11(11):623. doi: 10.1038/nrclinonc.2014.165. Epub 2014 Sep 30.
9
Genetic variants in inducible nitric oxide synthase gene are associated with the risk of radiation-induced lung injury in lung cancer patients receiving definitive thoracic radiation.诱导型一氧化氮合酶基因中的遗传变异与接受胸部根治性放疗的肺癌患者发生放射性肺损伤的风险相关。
Radiother Oncol. 2014 May;111(2):194-8. doi: 10.1016/j.radonc.2014.03.001. Epub 2014 Apr 17.
10
Molecular markers to predict clinical outcome and radiation induced toxicity in lung cancer.预测肺癌临床结局和放射诱导毒性的分子标志物。
J Thorac Dis. 2014 Apr;6(4):387-98. doi: 10.3978/j.issn.2072-1439.2013.12.04.