Nakahara Y, Nakahara Y, Ikegami Y, Ishida T, Ushida S, Mochizuki Y, Matsuyama E
Department of Medicine, Himeji National Hospital, Hyogo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Apr;28(4):651-5.
A 71-year-old man complained of mild dyspnea, and his chest X-ray showed a cavitating lesion accompanied by infiltrative changes in the right middle lobe. Percutaneous aspiration revealed numerous gram-positive and acid-fast branching rods. Morphological examination and biochemical tests of the colonies confirmed the diagnosis of pulmonary nocardiosis caused by nocardia asteroides. The patient was treated successfully with sulfamethoxazole-trimethoprim. It has been reported that approximately half of the patients with pulmonary nocardiosis have immunodeficiency, but our patient had no underlying disease. This disease has no characteristic clinical features, so diagnosis is difficult. As nocardia may involve the central nervous system leading to a poor prognosis, early diagnosis and prompt treatment are required to improve survival.
一名71岁男性主诉轻度呼吸困难,胸部X线显示右中叶有空洞性病变并伴有浸润性改变。经皮穿刺抽吸发现大量革兰氏阳性和抗酸分支杆菌。对菌落进行形态学检查和生化试验确诊为由星形诺卡菌引起的肺诺卡菌病。该患者用磺胺甲恶唑-甲氧苄啶治疗成功。据报道,大约一半的肺诺卡菌病患者有免疫缺陷,但我们的患者没有基础疾病。这种疾病没有特征性临床症状,因此诊断困难。由于诺卡菌可能累及中枢神经系统导致预后不良,需要早期诊断和及时治疗以提高生存率。