Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan.
Org Lett. 2012 Jan 6;14(1):244-7. doi: 10.1021/ol203021c. Epub 2011 Dec 6.
The first total synthesis of penostatin B has been accomplished by using a highly diastereoselective Pauson-Khand reaction and an efficient relay ring-closing metathesis for the construction of the basic carbon skeleton of the natural product as the key steps.
已通过使用高度非对映选择性的 Pauson-Khand 反应和有效的接力环 closing 复分解反应，实现了 penostatin B 的首次全合成，这两个反应是构建天然产物基本碳骨架的关键步骤。
