Prokaeva T B, Alekberova Z S, Manuĭlova L S, Simonova M V, Anan'eva L P
Klin Med (Mosk). 1990 Jun;68(6):42-4.
Examination of rheumatoid arthritis (RA) patients (52 males and 35 females) revealed secondary amyloidosis (SA) in 44.2% and 48.6% of patients, respectively. The disease was confirmed by amyloid deposits in biopsy specimens of gingival mucosa. As far as age-specific SA incidence is concerned, SA was more prevalent in elderly age-groups: 29.7% and 80% in males under and over 50, respectively; 15.4% and 68.2% in relevant women. The disease history in old patients was not long: 4.6 +/- 1.0 yr and 3.3 +/- 0.7 yr for males and females, respectively. Not a single case of amyloid deposit occurred in patients with systemic lupus erythematosus at the age over 60. The contribution of sex hormones and other factors to SA onset in RA is under discussion. An old age of RA patients and associated infection, especially urogenic, can predispose to SA development.
对类风湿性关节炎（RA）患者（52名男性和35名女性）的检查显示，男性和女性患者中分别有44.2%和48.6%出现继发性淀粉样变性（SA）。通过牙龈黏膜活检标本中的淀粉样沉积物确诊该病。就特定年龄的SA发病率而言，SA在老年人群中更为普遍：50岁以下和50岁以上男性中的发病率分别为29.7%和80%；相关女性中的发病率分别为15.4%和68.2%。老年患者的病程不长：男性和女性分别为4.6±1.0年和3.3±0.7年。60岁以上的系统性红斑狼疮患者未出现一例淀粉样沉积物病例。性激素和其他因素对RA患者SA发病的影响正在讨论中。RA患者的老年期及相关感染，尤其是泌尿源性感染，可能易导致SA的发生。
