Haelewyn Benoit, Chazalviel Laurent, Nicole Olivier, Lecocq Myriam, Risso Jean-Jacques, Abraini Jacques H
ERT 1083, UMR 6232, Université de Caen Basse Normandie, CNRS, CEA, Centre CYCERON, B,P, 5229, Boulevard Henri Becquerel, 14074 Caen cedex, France.
Med Gas Res. 2011 Apr 27;1(1):2. doi: 10.1186/2045-9912-1-2.
The use and benefits of normobaric oxygen (NBO) in patients suffering acute ischemic stroke is still controversial.
Here we show for the first time to the best of our knowledge that NBO reduces both NMDA-induced calcium influxes in vitro and NMDA-induced neuronal degeneration in vivo, but increases oxygen and glucose deprivation-induced cell injury in vitro and ischemia-induced brain damage produced by middle cerebral artery occlusion in vivo.
Taken together, these results indicate that NBO reduces excitotoxin-induced calcium influx and subsequent neuronal degeneration but favors ischemia-induced brain damage and neuronal death. These findings highlight the complexity of the mechanisms involved by the use of NBO in patients suffering acute ischemic stroke.
常压氧（NBO）在急性缺血性中风患者中的应用及益处仍存在争议。
据我们所知，我们首次表明，常压氧在体外可减少N-甲基-D-天冬氨酸（NMDA）诱导的钙内流，在体内可减少NMDA诱导的神经元变性，但在体外会增加氧和葡萄糖剥夺诱导的细胞损伤，在体内会增加大脑中动脉闭塞所致的缺血性脑损伤。
综上所述，这些结果表明，常压氧可减少兴奋性毒素诱导的钙内流及随后的神经元变性，但会加重缺血性脑损伤和神经元死亡。这些发现凸显了在急性缺血性中风患者中使用常压氧所涉及机制的复杂性。
