Ivanov A P, Goncharov I B, Repenkova L G
Kosm Biol Aviakosm Med. 1990 Jul-Aug;24(4):30-2.
Nine essentially healthy subjects, aged 25 to 42 years, were exposed to head-down bed rest (-8 degrees). On bed rest days 3, 7 and 14 the following rheological and hemodynamic parameters were measured: blood dynamic viscosity, Caisson viscosity, yield limit, red blood cell aggregation, stroke volume, cardiac output, and total peripheral resistance. Rheological parameters were measured by means of a rotation viscosimeter at 25 degrees C +/- 0.1. Hemodynamic parameters were measured by the method of integrated rheography. Blood was withdrawn from the cubital vein. The results give evidence that dynamic and Caisson viscosity increased significantly, reaching a peak by bed rest day 14. The sequence of hemodynamic changes followed the same pattern as rheological changes. Analysis of the results shows that there is a good correlation between the above parameters, especially by bed rest day 14. Thus, it can be concluded that there is a vascular mechanism involved in the compensatory restructuring of the vascular system at the tissue level in response to blood redistribution and fluid loss during bed rest.
9名年龄在25至42岁之间的基本健康受试者接受了头低位卧床休息（-8度）。在卧床休息的第3天、第7天和第14天，测量了以下流变学和血液动力学参数：血液动态粘度、卡森粘度、屈服极限、红细胞聚集、每搏输出量、心输出量和总外周阻力。流变学参数通过旋转粘度计在25℃±0.1下测量。血液动力学参数通过综合流变图法测量。从肘静脉采血。结果表明，动态粘度和卡森粘度显著增加，在卧床休息第14天达到峰值。血液动力学变化的顺序与流变学变化遵循相同模式。结果分析表明，上述参数之间存在良好的相关性，尤其是在卧床休息第14天时。因此，可以得出结论，在卧床休息期间，为应对血液重新分布和液体流失，在组织水平上血管系统的代偿性重构涉及一种血管机制。
