Matsuda Yuji, Kobayashi Misato, Yamauchi Rie, Ojika Makoto, Hiramitsu Masanori, Inoue Takashi, Katagiri Takao, Murai Atsushi, Horio Fumihiko
Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
Biosci Biotechnol Biochem. 2011;75(12):2309-15. doi: 10.1271/bbb.110452. Epub 2011 Dec 7.
We have previously demonstrated that coffee and caffeine ameliorated hyperglycemia in spontaneously diabetic KK-A(y) mice. This present study evaluates the antidiabetic effects of coffee and caffeine on high-fat-diet-induced impaired glucose tolerance in C57BL/6J mice. C57BL/6J mice fed a high-fat diet were given regular drinking water (control group), or a 2.5-fold-diluted coffee or caffeine solution (200 mg/L) for 17 weeks. The ingestion of coffee or caffeine improved glucose tolerance, insulin sensitivity, and hyperinsulinemia when compared with mice in the control group. The adipose tissue mRNA levels of inflammatory adipocytokines (MCP-1 and IL-6) and the liver mRNA levels of genes related to fatty acid synthesis were lower in the coffee and caffeine groups than those in the control group. These results suggest that coffee and caffeine exerted an ameliorative effect on high-fat-diet-induced impaired glucose tolerance by improving insulin sensitivity. This effect might be attributable in part to the reduction of inflammatory adipocytokine expression.
我们之前已经证明，咖啡和咖啡因可改善自发性糖尿病KK-A(y)小鼠的高血糖状况。本研究评估了咖啡和咖啡因对高脂饮食诱导的C57BL/6J小鼠糖耐量受损的抗糖尿病作用。给喂食高脂饮食的C57BL/6J小鼠提供普通饮用水（对照组），或2.5倍稀释的咖啡或咖啡因溶液（200毫克/升），持续17周。与对照组小鼠相比，摄入咖啡或咖啡因可改善糖耐量、胰岛素敏感性和高胰岛素血症。咖啡和咖啡因组的脂肪组织中炎性脂肪因子（MCP-1和IL-6）的mRNA水平以及肝脏中与脂肪酸合成相关基因的mRNA水平均低于对照组。这些结果表明，咖啡和咖啡因通过改善胰岛素敏感性，对高脂饮食诱导的糖耐量受损发挥了改善作用。这种作用可能部分归因于炎性脂肪因子表达的降低。
