improves antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus: a randomized control trial.

may improve antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus (GDM). Black garlic was prepared with or without Volatile and polysaccharides were analyzed by using LC-MS, Fourier Transform infrared (FTIR) and C nuclear magnetic resonance (NMR). The study design was parallel randomized controlled trial and 226 GDM patients were randomly assigned into BG (black garlic and ) and CG (black garlic) groups, and allocation ratio was 1:1. The treatment duration was 40 weeks. Fasting blood glucose (FBG) and 1- and 2-h blood glucose (1hBG and 2hBG) after oral glucose tolerance test (OGTT) were detected. Antioxidant function of black garlic was determined by measuring plasma malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and total antioxidant capacity (T-AOC) in GDM patients. The comparison between two groups was made using two independent samples test. The intake of nutrients was similar between two groups (>0.05). promoted the transformation of the glucopyranoside to glucofuranoside. increased the abilities of black garlic for scavenging hydroxyl radicals, 2,2'-azino-bis (3-ethylbenzenthiazoline-6-sulfonic) acid (ABTS) and DPPH free radicals. reduced the levels of FBG, 1hBG and 2hBG, and incidence of perinatal complications (<0.01). Plasma MDA level in the BG group was lower than in the CG group, whereas the levels of SOD, GSH-PX and T-AOC in the BG group were higher than in the CG group (<0.01). improves antioxidant capacity of black garlic in the prevention of GDM.