Sutera S P, Mueller E R, Zahalak G I
Department of Mechanical Engineering, Washington University, St Louis, MO 63130.
J Biomech Eng. 1990 Aug;112(3):250-6. doi: 10.1115/1.2891181.
Normal human erythrocytes suspended in shear flow are stretched into quasi ellipsoidal forms while their membranes rotate smoothly (tank-treading). Following abrupt cessation of shear the cells recover their discoidal shapes approximately exponentially, in the manner of a Kelvin-Voigt (K-V) solid. To test the hypothesis that the recovery process is membrane-controlled, the effects of initial deformation, cytoplasmic viscosity and membrane surface-to-volume ratio were studied. It was concluded that the membrane dynamics dominates the transient shape recovery, and that the characteristic recovery time is dependent on the initial deformation. Hence, the usual simplified analysis based on retraction of a plane sheet of K-V material with constant moduli appears to be an inadequate treatment of transient whole cell recovery.
悬浮在剪切流中的正常人体红细胞会被拉伸成准椭圆形，同时其细胞膜会平稳旋转（像坦克履带一样转动）。剪切突然停止后，细胞会以开尔文 - 沃伊特（K - V）固体的方式近似指数地恢复其盘状形状。为了检验恢复过程受膜控制这一假设，研究了初始变形、细胞质粘度和膜表面积与体积比的影响。得出的结论是，膜动力学主导了瞬时形状恢复，且特征恢复时间取决于初始变形。因此，基于具有恒定模量的K - V材料平面片收缩的常用简化分析似乎不足以处理整个细胞的瞬时恢复。
