Santoro Silvina G, Guida Alberto H, Furioso Alejandra E, Glikman Patricia, Rogozinski Amelia S
Department of Endocrinology, Hospital General de Agudos Dr. Profesor J. M. Ramos Mejía, Argentina.
Arq Bras Endocrinol Metabol. 2011 Oct;55(7):481-5. doi: 10.1590/s0004-27302011000700008.
Wegener's granulomatosis (WG) is a multi-system necrotizing granulomatous vasculitis which classically affects the upper respiratory tract, lungs and kidneys. Pituitary participation has been described in 24 patients in the literature to date. The aim of this article is to report a case of pituitary involvement in WG, and to present a literature review on this association. We present a female patient with WG who evolved with central diabetes insipidus (CDI), panhypopituitarism, and mild hyperprolactinemia. MRI showed an infiltrative pattern. Pituitary involvement has been reported in around 1% of patients with WG, mostly in women. It is represented by CDI and hypopituitarism. MRI generally shows pituitary enlargement, stalk thickening and loss of hyperintensity of the neurohypophysis. Permanent endocrine therapy is generally needed. WG should be considered in cases of CDI and hypopituitarism, essentially if a vasculitis is suspected and more common sellar disorders have been ruled out.
韦格纳肉芽肿（WG）是一种多系统坏死性肉芽肿性血管炎，典型地累及上呼吸道、肺和肾脏。迄今为止，文献中已报道24例垂体受累的病例。本文旨在报告1例WG累及垂体的病例，并对这种关联进行文献综述。我们报告1例患有WG的女性患者，其出现了中枢性尿崩症（CDI）、全垂体功能减退和轻度高泌乳素血症。磁共振成像（MRI）显示为浸润性表现。据报道，约1%的WG患者会出现垂体受累，大多数为女性。其表现为CDI和垂体功能减退。MRI通常显示垂体增大、垂体柄增粗以及神经垂体高信号消失。一般需要长期进行内分泌治疗。对于CDI和垂体功能减退的病例，应考虑WG，尤其是在怀疑有血管炎且已排除更常见的鞍区疾病时。
