Extraction Laboratory, Center for Research in Biodiversity, Paulista University, São Paulo, SP, Brazil.
Braz Oral Res. 2011 Nov-Dec;25(6):519-25. doi: 10.1590/s1806-83242011000600008.
Squamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located within the Brazilian forests, but little is known about the chemical and/or pharmacological potential of these plants. Certain extracts obtained from Amazon and Atlantic Forest plants have previously been shown to have cytotoxic activity against various cancers. The aim of this study was to screen these extracts for cytotoxic activity against oral SCC cells. The extracts were analyzed for activity against the KB-ADL#12 cell line at various concentrations up to a maximum dose of 100 µg/mL. Comparisons with a control group were performed using one-way ANOVA. Significant cytotoxicity was induced by the extracts obtained from the aerial parts of Picrolemma sprucei (Simaroubaceae), from the leaves and stems of Laetia suaveolens (Salicaceae), from the aerial parts of Abarema auriculata (Fabaceae-Mimosoideae) and from the stem of A. auriculata.
鳞状细胞癌（SCC）是口腔最常见的癌症，也是男性中第五大最常见的恶性肿瘤。许多研究人员试图开发新的治疗方法，以改善 SCC 患者的预后。世界上超过 20%的生物多样性位于巴西森林中，但对这些植物的化学和/或药理学潜力知之甚少。先前已经证明从亚马逊和大西洋森林植物中获得的某些提取物对各种癌症具有细胞毒性活性。本研究旨在筛选这些提取物对口腔 SCC 细胞的细胞毒性活性。在高达 100 µg/mL 的最大剂量下，在各种浓度下分析提取物对 KB-ADL#12 细胞系的活性。使用单向方差分析与对照组进行比较。从 Picrolemma sprucei（Simaroubaceae）的地上部分、Laetia suaveolens（Salicaceae）的叶和茎、Abarema auriculata（Fabaceae-Mimosoideae）的地上部分和 A. auriculata 的茎中获得的提取物诱导了显著的细胞毒性。
