Cohen J R, Sarfati I, Ratner L, Tilson D
Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
J Surg Res. 1990 Oct;49(4):319-21. doi: 10.1016/0022-4804(90)90029-2.
The alpha 1-antitrypsin phenotypes were determined in 47 patients with abdominal aortic aneurysms. The MM phenotype was present in 85%, the MS phenotype in 4%, the MZ phenotype in 11%, and the ZZ phenotype not present in any patients. The MZ phenotype occurred significantly more often in patients with aneurysms than would be expected in the general population. The current data would support a genetic mechanism of either autosomal-dominant or multifactorial influences but not an X-linked mechanism for families with a history of abdominal aortic aneurysms.
对47例腹主动脉瘤患者进行了α1-抗胰蛋白酶表型测定。MM表型占85%，MS表型占4%，MZ表型占11%，未发现ZZ表型患者。与一般人群预期相比，MZ表型在动脉瘤患者中出现的频率显著更高。目前的数据支持常染色体显性或多因素影响的遗传机制，但不支持有腹主动脉瘤家族史的家庭存在X连锁机制。
