Wetsch Wolfgang A, Lahm Tim, Hinkelbein Jochen, Happel Christoph M, Padosch Stephan A
Anasthesiol Intensivmed Notfallmed Schmerzther. 2011 Nov;46(11-12):718-25. doi: 10.1055/s-0031-1297178. Epub 2011 Dec 6.
Acute right heart failure (RHF) is a frequent and severe complication during perioperative and intensive care treatment in intensive care units (ICUs). The most common causes are pulmonary hypertension, left heart failure, pulmonary embolism, sepsis, acute lung injury (ALI) and thoracosurgical procedures. Acute RHF is not only a major contributor to morbidity and mortality; it also influences efficacy and outcome of routinely performed procedures, such as vasopressors, in critically ill patients. In contrast to the left ventricle, the right ventricle's physiology and pathophysiology are understudied, and the diagnosis of acute RHF is frequently challenging. Although many drugs are available for the treatment of RHF, randomized trials for this setting are still missing. This article gives an overview of aetiology and pathogenesis of RHF and reviews the diagnostic and therapeutic interventions currently available for providers in anaesthesiology and critical care.
急性右心衰竭(RHF)是重症监护病房(ICU)围手术期及重症监护治疗期间常见且严重的并发症。最常见的病因包括肺动脉高压、左心衰竭、肺栓塞、脓毒症、急性肺损伤(ALI)以及胸外科手术。急性RHF不仅是发病和死亡的主要原因;它还会影响危重症患者常规治疗手段(如血管加压药)的疗效及预后。与左心室相比,右心室的生理和病理生理情况研究较少,急性RHF的诊断也常常具有挑战性。尽管有许多药物可用于治疗RHF,但针对这种情况的随机试验仍然缺乏。本文概述了RHF的病因及发病机制,并综述了目前麻醉学和重症监护领域医疗人员可采用的诊断和治疗干预措施。