Magini A, Pazzagli M, Salerno R, Simonis M, Mustacchi G, Serio M
Department of Clinical Physiopathology, University of Florence, Italy.
J Steroid Biochem. 1990 Aug 28;36(6):523-6. doi: 10.1016/0022-4731(90)90168-r.
For many years, hypersecretion of estrogens has been suspected of being one of the major risk factors of breast cancer for premenopausal women. Seventeen premenopausal women, who had undergone lumpectomy because of breast cancer (T1a No Mo) 3 yr before entering the study, were compared to 9 normal women of similar age, parity and body weight. A chemiluminescent method was used for the determination of estrone-3-glucuronide (E1-3G) and pregnanediol-3-glucuronide (Pd-3G) in early morning urine samples collected for an entire menstrual cycle of each of the 26 subjects. During the follicular phase, no significant differences in E1-3G and/or Pd-3G excretion were found between the two groups. During the luteal phase the E1-3G/Pd-3G ratio in the early, middle and late luteal phase had significantly increased in the women with breast cancer, in spite of normal Pd-3G excretion. Therefore, the measurement of glucuronoconjugate metabolites of ovarian hormones in overnight urine might be conveniently applied to the study of ovarian function in subjects with breast cancer. Furthermore, the results of this study may indicate that an estrogen/progesterone imbalance is an additional risk factor for the premenopausal breast cancer patient.
多年来，雌激素分泌过多一直被怀疑是绝经前女性患乳腺癌的主要风险因素之一。17名绝经前女性在进入本研究前3年因乳腺癌（T1a No Mo）接受了肿块切除术，将她们与9名年龄、生育状况和体重相似的正常女性进行比较。采用化学发光法测定26名受试者每人整个月经周期清晨尿液样本中的雌酮-3-葡萄糖醛酸苷（E1-3G）和孕二醇-3-葡萄糖醛酸苷（Pd-3G）。在卵泡期，两组之间的E1-3G和/或Pd-3G排泄量没有显著差异。在黄体期，尽管Pd-3G排泄正常，但乳腺癌患者在黄体早期、中期和晚期的E1-3G/Pd-3G比值显著升高。因此，测定过夜尿液中卵巢激素的葡萄糖醛酸结合代谢物可能便于应用于乳腺癌患者卵巢功能的研究。此外，本研究结果可能表明，雌激素/孕酮失衡是绝经前乳腺癌患者的另一个风险因素。
