Ahn In Su, Chung Bo Young, Cho Soo Ick, Kim Hye One, Park Chun Wook, Lee Cheol Heon
Department of Dermatology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
Ann Dermatol. 2011 Oct;23(Suppl 2):S182-4. doi: 10.5021/ad.2011.23.S2.S182. Epub 2011 Oct 31.
Tacrolimus, a calcineurin inhibitor, formerly also known as FK506, is a macrolactam drug isolated from Streptomyces tsukubaensis. Its mode of action closely parallels the action of cyclosprorin A (CsA) and can be used for the treatment of inflammatory and autoimmune skin diseases in which systemic CsA has proved effective against psoriasis, pyoderma gangrenosum, atopic dermatitis, lupus erythematosus and graft versus host disease (GVHD). Although several cases of epidermal cysts have been reported in patients using cyclosporine and other immunosuppressants after organ transplantation; such types of cases have yet not been reported after administration of tacrolimus. However, we report herein a case of presence of multiple, various sized epidermal cysts in a renal transplant recipient receiving tacrolimus.
他克莫司是一种钙调神经磷酸酶抑制剂，以前也称为FK506，是从筑波链霉菌中分离出的一种大环内酰胺类药物。其作用方式与环孢素A（CsA）的作用密切相似，可用于治疗炎症性和自身免疫性皮肤病，在这些疾病中，全身性CsA已被证明对银屑病、坏疽性脓皮病、特应性皮炎、红斑狼疮和移植物抗宿主病（GVHD）有效。尽管有几例器官移植后使用环孢素和其他免疫抑制剂的患者出现表皮囊肿的报道；但使用他克莫司后尚未有此类病例的报道。然而，我们在此报告一例接受他克莫司治疗的肾移植受者出现多个大小不一的表皮囊肿的病例。
