al-Khalil S, Aqel M, Afifi F, al-Eisawi D
Faculty of Pharmacy, University of Jordan, Amman.
J Ethnopharmacol. 1990 Aug;30(1):35-42. doi: 10.1016/0378-8741(90)90015-l.
The effects of an aqueous extract of Ferula ovina were tested in vitro using isolated segments of rabbit and guinea pig intestine, trachea and aorta. The extract inhibited the spontaneous movements of rabbit jejunum and guinea pig ileum and the contractions induced by acetylcholine. The aqueous extract also inhibited the contractions of rabbit trachealis muscle induced by acetylcholine and the contractions of guinea pig trachealis muscle induced by histamine. These inhibitions were dose-dependent and reversible. However, the aqueous extract did not inhibit the contractions of rabbit and guinea pig aortic rings induced by norepinephrine. These data suggest that this plant has non-specific anticholinergic and antihistaminic antispasmodic effects.
采用兔和豚鼠的离体肠段、气管及主动脉段，对阿魏（Ferula ovina）水提取物的作用进行了体外试验。该提取物抑制兔空肠和豚鼠回肠的自发运动以及乙酰胆碱诱导的收缩。水提取物还抑制乙酰胆碱诱导的兔气管平滑肌收缩以及组胺诱导的豚鼠气管平滑肌收缩。这些抑制作用呈剂量依赖性且可逆。然而，水提取物不抑制去甲肾上腺素诱导的兔和豚鼠主动脉环收缩。这些数据表明该植物具有非特异性抗胆碱能和抗组胺的解痉作用。
