Faculdade de Farmácia, Instituto de Toxicologia, Pontíficia Universidade Católica do Rio Grande do Sul, Av Ipiranga 6681, Prédio 12 D, Porto Alegre 90630-180, Rio Grande do Sul, Brazil.
Int J Environ Health Res. 2012;22(3):279-86. doi: 10.1080/09603123.2011.634389. Epub 2011 Dec 9.
The determination of cholinesterase activity in plasma and erythrocytes serves as a useful and sensitive biomarker of exposure to organophosphorus and carbamate pesticides. However, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity may be influenced by factors such as age, gender, drugs, and physical exercise. The aim of this study was to evaluate the effects of gender and physical exercise on the activity of AChE and BuChE in healthy individuals. The values for both enzymes were lower for women. Physical exercise increased the levels of BuChE, and had no significant effect on AChE. To our knowledge, this is the first clinical study evaluating the influence of physical exercise in levels of these enzymes. Considering that cholinesterase activity is a useful parameter in assessing the exposure of individuals to pesticides, it is important to understand factors that influence the determination of the enzymes in order to avoid the erroneous interpretation of results.
测定血浆和红细胞中的胆碱酯酶活性可作为接触有机磷和氨基甲酸酯类农药的有用且敏感的生物标志物。然而，乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BuChE）的活性可能受到年龄、性别、药物和体育锻炼等因素的影响。本研究旨在评估性别和体育锻炼对健康个体中 AChE 和 BuChE 活性的影响。两种酶的女性值较低。体育锻炼增加了 BuChE 的水平，对 AChE 没有显著影响。据我们所知，这是第一项评估体育锻炼对这些酶水平影响的临床研究。鉴于胆碱酯酶活性是评估个体接触杀虫剂的有用参数，了解影响酶测定的因素对于避免错误解释结果非常重要。
