硫化氢在糖尿病及其并发症发病机制中的作用。
Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications.
机构信息
Department of Anesthesiology, The University of Texas Medical Branch at Galveston, 601 Harborside Drive, Galveston, TX 77555, USA.
出版信息
Antioxid Redox Signal. 2012 Jul 1;17(1):68-80. doi: 10.1089/ars.2011.4451. Epub 2012 Jan 30.
SIGNIFICANCE
Diabetes and its complications represent a major socioeconomic problem.
RECENT ADVANCES
Changes in the balance of hydrogen sulfide (H(2)S) play an important role in the pathogenesis of β-cell dysfunction that occurs in response to type 1 and type 2 diabetes. In addition, changes in H(2)S homeostasis also play a role in the pathogenesis of endothelial injury, which develop on the basis of chronically or intermittently elevated circulating glucose levels in diabetes.
CRITICAL ISSUES
In the first part of this review, experimental evidence is summarized implicating H(2)S overproduction as a causative factor in the pathogenesis of β-cell death in diabetes. In the second part of our review, experimental evidence is presented supporting the role of H(2)S deficiency (as a result of increased H(2)S consumption by hyperglycemic cells) in the pathogenesis of diabetic endothelial dysfunction, diabetic nephropathy, and cardiomyopathy.
FUTURE DIRECTIONS
In the final section of the review, future research directions and potential experimental therapeutic approaches around the pharmacological modulation of H(2)S homeostasis in diabetes are discussed.
意义
糖尿病及其并发症是一个主要的社会经济问题。
最新进展
硫化氢 (H(2)S) 平衡的变化在 1 型和 2 型糖尿病中发生的 β 细胞功能障碍的发病机制中起着重要作用。此外，H(2)S 动态平衡的变化也在糖尿病患者中慢性或间歇性升高的循环葡萄糖水平基础上发生的内皮损伤的发病机制中起作用。
关键问题
在这篇综述的第一部分，总结了实验证据，表明 H(2)S 过度产生是糖尿病中 β 细胞死亡发病机制的一个原因。在我们综述的第二部分，提出了实验证据，支持 H(2)S 缺乏（由于高血糖细胞增加 H(2)S 的消耗）在糖尿病内皮功能障碍、糖尿病肾病和心肌病发病机制中的作用。
未来方向
在综述的最后一节中，讨论了围绕糖尿病中 H(2)S 动态平衡的药理学调节的未来研究方向和潜在的实验治疗方法。
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