Division of Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
COPD. 2011 Dec;8(6):421-8. doi: 10.3109/15412555.2011.629858.
A relationship between local and systemic inflammation and different co-morbidities, such as cardiovascular, has been discussed in relation to disease process and prognosis in COPD.
To evaluate if conditions as cardiovascular diseases, diabetes, chronic rhinitis and gastroesophageal reflux are overrepresented in COPD.
All subjects with COPD according to GOLD, FEV(1)/FVC<0.70, were identified (n = 993) from the clinical follow-up in 2002-04 of the OLIN (Obstructive Lung Disease in Northern Sweden) studies' cohorts together with 993 gender- and age-matched reference subjects without COPD (non-COPD, further divided into normal and restrictive lung function). Interview data on co-morbidity and symptoms were used.
Cardiovascular co-morbidity, taken together heart disease, hypertension, stroke and intermittent claudication, was the most common and higher in COPD compared to in normal lung function (Nlf) 50.1% vs 41.0% (p<0.001). The prevalence of chronic rhinitis and gastroesophageal reflux (GERD) was higher in COPD compared to in Nlf (43.1% vs 32.3%, p<0.001 and 16.7% vs 12.0%, p = 0.011). In restrictive lung function the prevalence of chronic rhinitis, cardiovascular disease, hyperlipemia and diabetes was higher compared to in Nlf (41.0% vs 32.3%, p = 0.017, 59.0% vs 41.0%, p<0.001, 29.2% vs.12.9%, p = 0.033, 20.9% vs 8.6%, p <0.001). In COPD and heart disease, 62.5% had chronic rhinitis and/or GERD, while in Nlf the corresponding proportion was 42.5%.
Co-morbid conditions such as cardiovascular disease, chronic rhinitis and gastroesophageal reflux were common in COPD. The overlap between heart disease, chronic rhinitis and GERD was large in COPD. Restrictive lung function did also identify a population with increased disease burden.
局部和全身炎症与心血管等不同合并症之间的关系已在 COPD 的疾病过程和预后方面进行了讨论。
评估心血管疾病、糖尿病、慢性鼻炎和胃食管反流等疾病在 COPD 中的发病率是否更高。
从 2002-04 年 OLIN（瑞典北部阻塞性肺病）研究队列的临床随访中确定了所有根据 GOLD 标准诊断为 COPD 的患者（FEV1/FVC<0.70，n=993），并与 993 名性别和年龄匹配的无 COPD 参考患者（非 COPD，进一步分为正常和限制性肺功能）。使用合并症和症状的访谈数据。
心血管合并症，包括心脏病、高血压、中风和间歇性跛行，在 COPD 中最为常见，且高于正常肺功能（Nlf）（50.1% vs 41.0%，p<0.001）。与 Nlf 相比，COPD 中慢性鼻炎和胃食管反流（GERD）的患病率更高（43.1% vs 32.3%，p<0.001 和 16.7% vs 12.0%，p=0.011）。在限制性肺功能中，与 Nlf 相比，慢性鼻炎、心血管疾病、高脂血症和糖尿病的患病率更高（41.0% vs 32.3%，p=0.017，59.0% vs 41.0%，p<0.001，29.2% vs.12.9%，p=0.033，20.9% vs 8.6%，p<0.001）。在 COPD 和心脏病患者中，62.5%有慢性鼻炎和/或 GERD，而在 Nlf 中，相应的比例为 42.5%。
心血管疾病、慢性鼻炎和胃食管反流等合并症在 COPD 中很常见。在 COPD 中，心脏病、慢性鼻炎和 GERD 之间存在较大的重叠。限制性肺功能也确定了一个疾病负担增加的人群。
