Department of Respiratory Medicine, Shizuoka General Hospital, 4-27-1 Kita-ando, Aoi, Shizuoka, Japan.
COPD. 2011 Dec;8(6):456-63. doi: 10.3109/15412555.2011.626818.
The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory system resistance (Rrs) and reactance (Xrs) at a wide range of frequencies during breathing at rest in a short time. The purpose of this study was to assess the differences in Rrs and Xrs between patients with chronic obstructive pulmonary disease (COPD) and asthma using a new method of FOT with colored 3-dimensional visualization.
Fifty-one patients with stable COPD and 49 patients with controlled or partly controlled asthma were enrolled. Whole-breath or within-breath changes of Rrs and Xrs were measured and compared between the diseases.
The colored 3-dimensional images clarified the complex oscillatory properties of the respiratory system. Whole-breath resistance (the difference in Rrs at 5 and 20 Hz) and reactance (Xrs at 5 Hz and resonant frequency), and within-breath changes in reactance (Xrs at 5 Hz and resonant frequency) discriminated between patients with COPD and asthma. In multivariate regression analyses, inspiratory-expiratory differences in Xrs at 5 Hz contributed significantly to the differentiation between COPD and asthma, independent of age, gender, body weight, and pulmonary function.
This new method of FOT is useful in the differential diagnosis of COPD and asthma.
强迫振荡技术（FOT）是一种非侵入性方法，可在短时间内测量休息时呼吸过程中呼吸道阻力（Rrs）和电抗（Xrs）在较宽频率范围内的变化。本研究的目的是使用彩色三维可视化新技术评估慢性阻塞性肺疾病（COPD）和哮喘患者的 Rrs 和 Xrs 差异。
纳入 51 例稳定期 COPD 患者和 49 例控制或部分控制的哮喘患者。测量并比较了两种疾病之间整个呼吸周期和呼吸内的 Rrs 和 Xrs 的变化。
彩色三维图像阐明了呼吸系统的复杂振荡特性。全呼吸阻力（5Hz 和 20Hz 时 Rrs 的差异）和电抗（5Hz 时的 Xrs 和共振频率）以及呼吸内电抗变化（5Hz 时的 Xrs 和共振频率）可区分 COPD 和哮喘患者。多元回归分析表明，5Hz 时的吸气-呼气电抗差异对 COPD 和哮喘的鉴别具有重要意义，与年龄、性别、体重和肺功能无关。
这种新的 FOT 方法可用于 COPD 和哮喘的鉴别诊断。
