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急性胰腺炎早期的丙二醛。

Malondialdehyde in early phase of acute pancreatitis.

机构信息

Department of Gastroenterology, Hospital Clínico Universitario de Valencia, Universitat de València, València, Spain.

出版信息

Rev Esp Enferm Dig. 2011 Nov;103(11):563-9. doi: 10.4321/s1130-01082011001100002.

Abstract

AIMS

to assess oxidative stress in acute pancreatitis, its evolution over time and its relationship with the severity of the disease.

METHODS

during a two-year period, patients with acute pancreatitis with less than 24 hours of pain were evaluated. Serum was obtained the first, second and fourth day from admittance, if complications were detected, and after recovery. Malondialdehyde was determined by high performance liquid chromatography. Twenty healthy volunteers constituted the control group. Malondialdehyde between groups was compared with Mann-Whitney and Kruskal-Wallis tests; malondialdehyde evolution was studied with Wilcoxon test.

RESULTS

one hundred and sixty-nine patients were included (91 women, median age 67 years, range 20-95); 33 suffered a severe episode. Malondialdehyde decreased from first to fourth day (0.600 vs. 0.451 vs. 0.343 M, respectively, p < 0.05). When complications were detected, malondialdehyde level was similar to that of first and second day (0.473 M, p > 0.05). In severe attacks malondialdehyde was higher than in control group at day 2 (severe: 0.514; mild: 0.440; control: 0.347 M, p < 0.05 severe vs. control).

CONCLUSIONS

an early oxidative stress is observed in acute pancreatitis. In severe attacks, oxidative stress remains high longer than in mild episodes. The onset of complications is associated with high malondialdehyde concentration.

摘要

目的

评估急性胰腺炎中的氧化应激,及其随时间的演变及其与疾病严重程度的关系。

方法

在两年期间,评估了疼痛发作时间少于 24 小时的急性胰腺炎患者。在入院的第 1、2 和 4 天,如果发现并发症,则在恢复后获得血清。通过高效液相色谱法测定丙二醛。20 名健康志愿者构成对照组。用 Mann-Whitney 和 Kruskal-Wallis 检验比较组间丙二醛;用 Wilcoxon 检验研究丙二醛的演变。

结果

共纳入 169 例患者(91 例女性,中位年龄 67 岁,范围 20-95 岁);33 例患者发生严重发作。丙二醛从第 1 天到第 4 天逐渐下降(分别为 0.600、0.451 和 0.343 M,p <0.05)。当发现并发症时,丙二醛水平与第 1 天和第 2 天相似(0.473 M,p >0.05)。在严重发作时,丙二醛在第 2 天高于对照组(严重:0.514;轻度:0.440;对照组:0.347 M,p <0.05 严重 vs. 对照组)。

结论

急性胰腺炎中存在早期氧化应激。在严重发作时,氧化应激的持续时间长于轻度发作。并发症的发生与丙二醛浓度升高有关。

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