Medisch Centrum Oost, University of Amsterdam, Amsterdam, the Netherlands.
Diabet Med. 2012 Jun;29(6):796-802. doi: 10.1111/j.1464-5491.2011.03552.x.
To explore which factors are associated with psychological insulin resistance in insulin-naive patients with Type 2 diabetes in primary care.
A sample of 101 insulin-naive patients with Type 2 diabetes completed self-administered questionnaires including demographic and clinical characteristics, the Insulin Treatment Appraisal Scale and the Center for Epidemiological Studies Depression scale. Psychological insulin resistance was denoted by negative appraisal of insulin (Insulin Treatment Appraisal Scale).
Thirty-nine per cent of the sample were unwilling to accept insulin therapy. Unwilling participants perceived taking insulin more often as a failure to control their diabetes with tablets or lifestyle compared with willing participants (59 vs. 33%), unwilling participants were more reluctant to accept the responsibilities of everyday management of insulin therapy (49 vs. 24%). Multiple linear regression analysis revealed that depression and objection to lifelong insulin therapy were independently associated with psychological insulin resistance.
In this study in primary care, depression and objection to lifelong insulin therapy are associated with psychological insulin resistance. Analysis of the objection to the indefiniteness of insulin therapy showed a sense of limitation of daily life and loss of independence that should not be underestimated. Insulin should be offered as a means to improve health as this might facilitate the acceptance of insulin therapy.
探讨初级保健中,哪些因素与 2 型糖尿病初诊胰岛素治疗患者的心理胰岛素抵抗相关。
101 例 2 型糖尿病初诊胰岛素治疗患者完成了自我管理调查问卷,包括人口统计学和临床特征、胰岛素治疗评估量表和流行病学研究中心抑郁量表。心理胰岛素抵抗表示为对胰岛素的负面评价(胰岛素治疗评估量表)。
样本中 39%的患者不愿意接受胰岛素治疗。与愿意接受胰岛素治疗的患者相比,不愿意接受胰岛素治疗的患者认为,与口服药物或生活方式相比,使用胰岛素更频繁地意味着他们无法控制糖尿病(59%比 33%);与愿意接受胰岛素治疗的患者相比,不愿意接受胰岛素治疗的患者更不愿意承担胰岛素治疗日常管理的责任(49%比 24%)。多元线性回归分析显示,抑郁和反对终身胰岛素治疗与心理胰岛素抵抗独立相关。
在本项初级保健研究中,抑郁和反对终身胰岛素治疗与心理胰岛素抵抗相关。对胰岛素治疗的不确定性的反对分析显示出对日常生活的限制感和丧失独立性,这一点不应被低估。应该将胰岛素作为改善健康的手段提供,这可能有助于接受胰岛素治疗。