Psychobiology of Stress and Health Lab, Psychology Department, Sackville, New Brunswick, Canada.
J Inflamm (Lond). 2011 Dec 7;8(1):37. doi: 10.1186/1476-9255-8-37.
We examined salivary C-reactive protein (CRP) levels in the context of tobacco smoke exposure (TSE) in healthy youth. We hypothesized that there would be a dose-response relationship between TSE status and salivary CRP levels.
This work is a pilot study (N = 45) for a larger investigation in which we aim to validate salivary CRP against serum CRP, the gold standard measurement of low-grade inflammation. Participants were healthy youth with no self-reported periodontal disease, no objectively measured obesity/adiposity, and no clinical depression, based on the Beck Depression Inventory (BDI-II). We assessed tobacco smoking and confirmed smoking status (non-smoking, passive smoking, and active smoking) with salivary cotinine measurement. We measured salivary CRP by the ELISA method. We controlled for several potential confounders.
We found evidence for the existence of a dose-response relationship between the TSE status and salivary CRP levels.
Our preliminary findings indicate that salivary CRP seems to have a similar relation to TSE as its widely used serum (systemic inflammatory) biomarker counterpart.
我们研究了健康年轻人在烟草烟雾暴露（TSE）背景下的唾液 C 反应蛋白（CRP）水平。我们假设 TSE 状况与唾液 CRP 水平之间存在剂量反应关系。
这是一项更大规模研究的初步研究（N=45），旨在验证唾液 CRP 与血清 CRP 的相关性，后者是低度炎症的金标准测量方法。参与者为无自我报告牙周病、无客观测量肥胖/脂肪过多且无临床抑郁（根据贝克抑郁量表 II 评估）的健康年轻人。我们评估了烟草吸烟情况，并通过唾液可替宁测量来确认吸烟状况（非吸烟、被动吸烟和主动吸烟）。我们采用 ELISA 法测量唾液 CRP。我们控制了几个潜在的混杂因素。
我们发现 TSE 状况与唾液 CRP 水平之间存在剂量反应关系的证据。
我们的初步发现表明，唾液 CRP 似乎与 TSE 及其广泛使用的血清（全身炎症）生物标志物具有相似的关系。
