Department of Epidemiology, School of Public Health, Aarhus University, Bartholins Allé 2, Aarhus C, Denmark.
Br J Nutr. 2012 Sep;108(5):924-31. doi: 10.1017/S0007114511006039. Epub 2011 Dec 12.
Fish consumption is the major dietary source of EPA and DHA, which according to rodent experiments may reduce body fat mass and prevent obesity. However, human studies have suggested that fish consumption has no appreciable association with body-weight gain. We investigated the associations between fish consumption and subsequent change in waist circumference. Sex, age and waist circumference at enrolment were considered as potential effect modifiers. Women and men (n 89 432) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 5·5 years. Mixed-effect linear regression was used to investigate the associations between fish consumption and subsequent change in waist circumference. Among all participants, the average annual change in waist circumference was - 0·01 cm/10 g higher total fish consumption per d (95 % CI - 0·01, 0·00) and - 0·01 cm/10 g higher fatty fish consumption per d (95 % CI - 0·02, - 0·01), after adjustment for potential confounders. Lean fish consumption was not associated with change in waist circumference. Adjustment for potential over- or underestimation of fish consumption measurements did not systematically change the observed associations, but the 95 % CI became slightly wider. The results in subgroups from analyses stratified by sex, age or waist circumference at enrolment were not systematically different. In conclusion, the present study suggests that fish consumption does not prevent increase in waist circumference.
鱼类消费是 EPA 和 DHA 的主要膳食来源，根据啮齿动物实验，鱼类消费可能会减少体脂肪量并预防肥胖。然而，人体研究表明，鱼类消费与体重增加没有明显关联。我们研究了鱼类消费与随后腰围变化之间的关联。性别、年龄和入组时的腰围被视为潜在的效应修饰剂。参与欧洲癌症与营养前瞻性调查（EPIC）的女性和男性（n=89432）随访中位数为 5.5 年。使用混合效应线性回归来研究鱼类消费与随后腰围变化之间的关联。在所有参与者中，与每天增加 10 克总鱼类消费相比，腰围的平均年变化量低 0.01 厘米（95%CI：-0.01，0.00），与每天增加 10 克高脂肪鱼类消费相比，腰围的平均年变化量低 0.01 厘米（95%CI：-0.02，-0.01），在调整潜在混杂因素后。瘦鱼类消费与腰围变化无关。调整潜在的鱼类消费测量值过高或过低估计并不会系统地改变观察到的关联，但 95%CI 变得稍宽。按性别、年龄或入组时腰围分层分析的亚组结果没有系统差异。总之，本研究表明鱼类消费并不能预防腰围增加。
