Department of Endocrinology, Heinrich-Heine-University, Duesseldorf, Germany.
Clin Exp Rheumatol. 2011 Nov-Dec;29(6):1021-3. Epub 2011 Dec 22.
Adult onset Still's disease (AOSD) is an uncommon, systemic, inflammatory disorder of unknown etiology, characterised by spiking fevers, skin rash, and arthritis. Treatment consists of glucocorticosteroids and immunosuppressive drugs. Over the last few years it has become increasingly evident that treatment with the IL-1 receptor antagonist (IL-1RA) anakinra is highly effective even in patients with intractable disease. So far, there are scant data available on the effects of anakinra in pregnancy. We report two patients with AOSD who successfully gave birth while treated with anakinra during pregnancy.
成人斯蒂尔病（AOSD）是一种罕见的、全身性的、病因不明的炎症性疾病，其特征是突发高热、皮疹和关节炎。治疗包括糖皮质激素和免疫抑制剂。在过去的几年中，越来越明显的是，即使对于难治性疾病患者，使用白细胞介素-1 受体拮抗剂（IL-1RA）阿那白滞素治疗也是非常有效的。到目前为止，关于阿那白滞素在妊娠中的作用的数据还很少。我们报告了 2 例 AOSD 患者，她们在妊娠期间使用阿那白滞素治疗，成功分娩。
