Institut National de la Recherche Agronomique, Unité de Recherche 1282, Infectiologie Animale et Santé Publique, 37380, Nouzilly (Tours), France.
Trends Microbiol. 2012 Jan;20(1):50-7. doi: 10.1016/j.tim.2011.11.002. Epub 2011 Dec 5.
An animal model to study human infectious diseases should accurately reproduce the various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of anatomy, genetics and physiology, and represent an excellent animal model to study various microbial infectious diseases. Indeed, experiments in pigs are much more likely to be predictive of therapeutic treatments in humans than experiments in rodents. In this review, we highlight the numerous advantages of the pig model for infectious disease research and vaccine development and document a few examples of human microbial infectious diseases for which the use of pigs as animal models has contributed to the acquisition of new knowledge to improve both animal and human health.
一种用于研究人类传染病的动物模型应能准确再现疾病的各个方面。家猪（Sus scrofa domesticus）在解剖学、遗传学和生理学方面与人类密切相关，是研究各种微生物传染病的极佳动物模型。实际上，在猪身上进行的实验比在啮齿动物身上进行的实验更有可能预测对人类的治疗效果。在这篇综述中，我们强调了猪模型在传染病研究和疫苗开发方面的诸多优势，并记录了一些人类微生物传染病的例子，这些疾病的研究使用猪作为动物模型有助于获得新知识，从而改善动物和人类的健康。
