应用生物发光成像技术对两种转移性嗜铬细胞瘤小鼠模型进行特征分析。
Characterization of two mouse models of metastatic pheochromocytoma using bioluminescence imaging.
机构信息
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892-1109, USA.
出版信息
Cancer Lett. 2012 Mar;316(1):46-52. doi: 10.1016/j.canlet.2011.10.019. Epub 2011 Oct 20.
Abstract
Pheochromocytoma is the most common tumor of the adrenal medulla in adults. The lack of sensitive animal models of pheochromocytoma has hindered the study of this tumor and in vivo evaluation of antitumor agents. In this study we generated two sensitive luciferase models using bioluminescent pheochromocytoma cells: an experimental metastasis model to monitor tumor spreading and a subcutaneous model to monitor tumor growth and spontaneous metastasis. These models offer a platform for sensitive, non-invasive and real-time monitoring of pheochromocytoma primary growth and metastatic burden to follow the course of tumor progression and for testing relevant antitumor treatments in metastatic pheochromocytoma.
摘要
嗜铬细胞瘤是成年人肾上腺髓质中最常见的肿瘤。缺乏敏感的嗜铬细胞瘤动物模型阻碍了对这种肿瘤的研究和抗肿瘤药物的体内评估。在这项研究中，我们使用生物发光嗜铬细胞瘤细胞生成了两种敏感的荧光素酶模型：一个用于监测肿瘤扩散的实验转移模型，和一个用于监测肿瘤生长和自发转移的皮下模型。这些模型为敏感、非侵入性和实时监测嗜铬细胞瘤的原发性生长和转移负担提供了一个平台，以跟踪肿瘤进展的过程，并测试转移性嗜铬细胞瘤的相关抗肿瘤治疗。
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