Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Italy.
Autoimmun Rev. 2012 Jul;11(9):659-63. doi: 10.1016/j.autrev.2011.11.011. Epub 2011 Nov 30.
Hepatitis C virus infection (HCV) is one of the best mimes in medicine. About 40-70% of patients suffering from this disorder develop at least one extra-hepatic disorder that can have a rheumatic nature (arthralgias, arthritis, vasculitis and sicca syndrome) and must be differentiated from the primitive rheumatic diseases. In addition, HCV infection can also alter the laboratory tests. Several alterations of first line laboratory tests can be usually found in both chronic HCV infection and chronic inflammatory rheumatic disorders. In the present review we analyze the interference of HCV in tests more specifically used in rheumatology: rheumatoid factor and other autoantibodies (ANA, anti-ENA, ANCA, anti-DNA, antiphospholipid, anti-CCP). In patients suffering from HCV infection, the diagnosis of connective tissue diseases (CTD) or rheumatoid arthritis (RA) should be made only when the detected symptoms or laboratory data are not inducible by HCV, otherwise only a diagnosis of "possible CTD" or "possible RA" should be considered.
丙型肝炎病毒感染（HCV）是医学中模仿能力最强的病原体之一。大约 40-70%的患有这种疾病的患者会出现至少一种肝外疾病，这些疾病可能具有风湿性质（关节痛、关节炎、血管炎和干燥综合征），必须与原发性风湿病相区别。此外，HCV 感染还会改变实验室检查。在慢性 HCV 感染和慢性炎症性风湿性疾病中，通常可以发现几种一线实验室检查的改变。在本综述中，我们分析了 HCV 对风湿科更具体使用的检查的干扰：类风湿因子和其他自身抗体（ANA、抗 ENA、抗中性粒细胞胞浆抗体、抗 DNA、抗磷脂、抗 CCP）。在患有 HCV 感染的患者中，只有当检测到的症状或实验室数据不能由 HCV 引起时，才应诊断为结缔组织疾病（CTD）或类风湿关节炎（RA），否则仅应考虑“可能的 CTD”或“可能的 RA”的诊断。
