丙型肝炎病毒感染及其对风湿病学的影响。
Hepatitis C virus infection and its rheumatologic implications.
作者信息
Sayiner Zeynel A, Haque Uzma, Malik Mohammad U, Gurakar Ahmet
机构信息
The authors are affiliated with the Johns Hopkins School of Medicine in Baltimore, Maryland. Dr Sayiner is a visiting research fellow in the Section of Gastroenterology and Hepatology. Dr Haque is an assistant professor in the Section of Rheumatology. Dr Malik is a research fellow in the Section of Gastroenterology and Hepatology. Dr Gurakar is the medical director of the Liver Transplant Program and an associate professor of medicine in the Section of Gastroenterology and Hepatology.
出版信息
Gastroenterol Hepatol (N Y). 2014 May;10(5):287-93.
Extrahepatic manifestations are frequently encountered among patients with chronic hepatitis C virus (HCV) infection. Many of these manifestations are autoimmune disorders, with added mortality and morbidity due to involvement of multiple organ systems. Symptoms of HCV infection and rheumatic diseases may be similar and include arthralgia, myalgia, arthritis, and vasculitis. Also, serologic abnormalities may be found in both cases. Some treatment modalities for HCV infection, including interferon therapy, may aggravate the symptoms of rheumatic diseases, thus confounding clinical presentation. It is imperative to distinguish whether symptoms such as arthralgia, myalgia, and arthritis occur in patients with HCV infection due to primary chronic HCV infection or to a newly developed rheumatologic disease process.
慢性丙型肝炎病毒（HCV）感染患者经常出现肝外表现。其中许多表现为自身免疫性疾病，由于多器官系统受累，会增加死亡率和发病率。HCV感染和风湿性疾病的症状可能相似，包括关节痛、肌痛、关节炎和血管炎。此外，在这两种情况下都可能发现血清学异常。HCV感染的一些治疗方式，包括干扰素治疗，可能会加重风湿性疾病的症状，从而使临床表现变得复杂。必须区分关节痛、肌痛和关节炎等症状是由原发性慢性HCV感染引起，还是由新出现的风湿性疾病过程导致。
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