脉搏 CO- 氧饱和度测定法测定血容量。
Determination of blood volume by pulse CO-oximetry.
机构信息
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Physiol Meas. 2012 Jan;33(1):19-27. doi: 10.1088/0967-3334/33/1/19. Epub 2011 Dec 7.
The objective of this study was to determine whether changes in carboxyhaemoglobin (COHb) saturation following carbon monoxide (CO) rebreathing can be accurately detected by pulse CO-oximetry in order to determine blood volume. Noninvasive measurements of carboxyhaemoglobin saturation (SpCO) were continuously monitored by pulse CO-oximetry before, during and following 2 min of CO rebreathing. Reproducibility and accuracy of noninvasive blood volume measurements were determined in 16 healthy non-smoking individuals (15 males, age: 28 ± 2 years, body mass index: 25.4 ± 0.6 kg m(-2)) through comparison with blood volume measurements calculated from invasive measurements of COHb saturation. The coefficient of variation for noninvasive blood volume measurements performed on separate days was 15.1% which decreases to 9.1% when measurements were performed on the same day. Changes in COHb saturation and SpCO following CO rebreathing were strongly correlated (r = 0.90, p < 0.01), resulting in a significant correlation between invasive and noninvasive blood volume measurements (r = 0.83, p = 0.02). Changes in SpCO following CO rebreathing can be accurately detected by pulse CO-oximetry, which could potentially provide a simplified, convenient and reproducible method to rapidly determine blood volume in healthy individuals.
本研究旨在确定脉搏 CO- 血氧仪是否能准确检测一氧化碳（CO）再呼吸后碳氧血红蛋白（COHb）饱和度的变化，从而确定血容量。在 2 分钟的 CO 再呼吸过程中，通过脉搏 CO- 血氧仪连续监测非侵入性 COHb 饱和度（SpCO）的变化。通过与从 COHb 饱和度的侵入性测量计算得出的血容量测量值进行比较，在 16 名健康不吸烟个体（15 名男性，年龄：28 ± 2 岁，体重指数：25.4 ± 0.6 kg m(-2)) 中确定了非侵入性血容量测量的重现性和准确性。在不同日子进行的非侵入性血容量测量的变异系数为 15.1%，而在同一天进行测量时则降低至 9.1%。CO 再呼吸后 COHb 饱和度和 SpCO 的变化呈强相关（r = 0.90，p < 0.01），导致侵入性和非侵入性血容量测量之间存在显著相关性（r = 0.83，p = 0.02）。脉搏 CO- 血氧仪可以准确检测 CO 再呼吸后 SpCO 的变化，这可能为快速确定健康个体的血容量提供一种简化、方便和可重复的方法。
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