Cairns R A, Harris I, McCracken S, Mak T W
The Campbell Family Institute for Breast Cancer Research, Toronto, Ontario, Canada M5C2M9.
Cold Spring Harb Symp Quant Biol. 2011;76:299-311. doi: 10.1101/sqb.2011.76.012856. Epub 2011 Dec 12.
Although the generation of a distinctive metabolic profile is a well-known aspect of cancer, the significance of these adaptations and their potential for exploitation for anticancer therapy has not been fully appreciated until recently. Many oncogenic changes known to affect intracellular signaling pathways play an active role in mediating these metabolic changes, which, in turn, function to support cancer cell growth and replication. In this chapter, we discuss the most current findings in cancer cell metabolism in terms of their impact on tumor cell growth as well as their potential for identifying new targets for therapeutic intervention.
尽管独特代谢谱的产生是癌症的一个众所周知的方面，但直到最近，这些适应性变化的重要性及其在抗癌治疗中的潜在应用价值才得到充分认识。许多已知影响细胞内信号通路的致癌变化在介导这些代谢变化中发挥着积极作用，而这些代谢变化反过来又支持癌细胞的生长和复制。在本章中，我们将讨论癌细胞代谢的最新发现，包括它们对肿瘤细胞生长的影响以及识别治疗干预新靶点的潜力。
