Hashemi Mehrdad, Mohandesi Khosroshahi Elaheh, Asadi Saba, Tanha Mahsa, Ghatei Mohseni Forough, Abdolmohammad Sagha Ramina, Taheri Elham, Vazayefi Paria, Shekarriz Helya, Habibi Fatemeh, Mortazi Shaghayegh, Khorrami Ramin, Nabavi Noushin, Rashidi Mohsen, Taheriazam Afshin, Rahimzadeh Payman, Entezari Maliheh
Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Noncoding RNA Res. 2024 Aug 9;10:1-15. doi: 10.1016/j.ncrna.2024.08.002. eCollection 2025 Feb.
Cancer progression results from the dysregulation of molecular pathways, each with unique features that can either promote or inhibit tumor growth. The complexity of carcinogenesis makes it challenging for researchers to target all pathways in cancer therapy, emphasizing the importance of focusing on specific pathways for targeted treatment. One such pathway is the PI3K/Akt pathway, which is often overexpressed in cancer. As tumor cells progress, the expression of PI3K/Akt increases, further driving cancer advancement. This study aims to explore how ncRNAs regulate the expression of PI3K/Akt. NcRNAs are found in both the cytoplasm and nucleus, and their functions vary depending on their location. They can bind to the promoters of PI3K or Akt, either reducing or increasing their expression, thus influencing tumorigenesis. The ncRNA/PI3K/Akt axis plays a crucial role in determining cell proliferation, metastasis, epithelial-mesenchymal transition (EMT), and even chemoresistance and radioresistance in human cancers. Anti-tumor compounds can target ncRNAs to modulate the PI3K/Akt axis. Moreover, ncRNAs can regulate the PI3K/Akt pathway both directly and indirectly.
癌症进展源于分子通路的失调，每条通路都有促进或抑制肿瘤生长的独特特征。癌症发生的复杂性使得研究人员在癌症治疗中针对所有通路具有挑战性，这凸显了专注于特定通路进行靶向治疗的重要性。PI3K/Akt通路就是这样一条通路，它在癌症中常常过度表达。随着肿瘤细胞的进展，PI3K/Akt的表达增加，进一步推动癌症进展。本研究旨在探索非编码RNA如何调节PI3K/Akt的表达。非编码RNA存在于细胞质和细胞核中，其功能因其位置而异。它们可以与PI3K或Akt的启动子结合，要么降低要么增加其表达，从而影响肿瘤发生。非编码RNA/PI3K/Akt轴在决定人类癌症中的细胞增殖、转移、上皮-间质转化（EMT），甚至化疗耐药性和放疗抗性方面起着关键作用。抗肿瘤化合物可以靶向非编码RNA来调节PI3K/Akt轴。此外，非编码RNA可以直接和间接调节PI3K/Akt通路。
