Maurice Müller Laboratories, DKF, Bern, Switzerland.
Gut Microbes. 2011 Nov-Dec;2(6):353-7. doi: 10.4161/gmic.18604. Epub 2011 Nov 1.
How a mutualistic relationship between the intestinal microbiota and intestinal T cell compartments is established is important, as a breakdown of intestinal T cell homeostasis may cause inflammatory bowel diseases. A number of studies have shown that different bacterial species modulate the intestinal CD4(+) T cell compartment in different ways. We performed mechanistic in vivo studies that demonstrated the crucial requirement for regulatory T cells (Treg) and interleukin-10 (IL-10) in the induction of intestinal T cell homeostasis even following colonization with a completely benign microbiota. In the absence of a functional Treg response or IL-10 receptor signaling, the same bacteria that induced a Treg response in wild-type animals now induced T helper type 17 responses, without intestinal inflammation. Therefore, Treg, IL-10 and Th17 are crucial regulatory mechanisms in the intestine not only for controlling inflammation, but also to establish a continuum of CD4(+) T cell homeostasis upon commensal colonization.
肠道微生物群与肠道 T 细胞区室之间的共生关系如何建立非常重要，因为肠道 T 细胞的动态平衡可能会导致炎症性肠病。许多研究表明，不同的细菌物种以不同的方式调节肠道 CD4(+) T 细胞区室。我们进行了机制性的体内研究，即使在定植完全良性的微生物群后，也证明了调节性 T 细胞 (Treg) 和白细胞介素 10 (IL-10) 在诱导肠道 T 细胞动态平衡中的关键作用。在缺乏功能正常的 Treg 反应或 IL-10 受体信号的情况下，在野生型动物中诱导 Treg 反应的相同细菌现在诱导了 Th17 反应，而没有肠道炎症。因此，Treg、IL-10 和 Th17 是肠道中至关重要的调节机制，不仅可以控制炎症，还可以在共生定植时建立 CD4(+) T 细胞的连续动态平衡。
