诱导小鼠结肠黏膜中的 Treg 细胞：维持宿主-微生物群平衡的核心机制。
Induction of Treg cells in the mouse colonic mucosa: a central mechanism to maintain host-microbiota homeostasis.
机构信息
Department of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
出版信息
Semin Immunol. 2012 Feb;24(1):50-7. doi: 10.1016/j.smim.2011.11.009. Epub 2011 Dec 14.
CD4+ regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis.
CD4+ 调节性 T（Treg）细胞表达转录因子叉头框 P3（Foxp3），在维持免疫稳态中发挥关键作用。Treg 细胞在小鼠肠固有层中高度丰富，特别是在结肠中。最近使用无菌和定植小鼠的研究表明，肠道微生物群的特定成分影响 Treg 细胞的数量和功能。微生物群组成的大量变化与炎症性肠病有关。在这篇综述中，我们将讨论最近的发现，这些发现将小鼠的肠道微生物群与 Treg 反应以及肠道免疫稳态的维持联系起来。
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