Department of Pediatrics, Surgical Unit, Faculty of Medicine, University of Pecs, Pecs, Hungary.
Eur J Gastroenterol Hepatol. 2012 Mar;24(3):316-9. doi: 10.1097/MEG.0b013e32834ea639.
The pathogenesis of nonparasitic splenic cysts (NPSCs) has not been clarified completely. The aim of this multinational and multicentre retrospective study was to further elucidate the origin of NPSCs.
From 1980 to 2006, 50 children and adolescents were surgically treated for NPSC at six paediatric surgical centres in four European countries. The initial histology report of 35 NPSCs, 22 epidermoid cysts, 11 pseudocysts or post-traumatic cysts and two mesothelial cysts was available. Additional re-evaluation, including immunohistochemistry, to detect cytokeratin, carcino-embrionic antigen and mesothelioma antibody in the inner surface of the cysts was carried out. Special attention was given to the possibility of preceding trauma to the splenic area and whether it played a role in the genesis of NPSC.
The pathological re-evaluation showed 30 epidermoid cysts, four mesothelial cysts and one pseudocyst. Immunohistology revealed eight epidermoid and two mesothelial linings of the cysts in those 11 patients in whom pseudocyst was diagnosed originally. No pseudocyst was documented in those patients who had a history of previous blunt abdominal trauma but was not proved by ultrasound and computed tomography scan.
In contrast with the prevailing belief, it has been demonstrated that NPSCs are congenital in origin, and there is no clinically proven evidence that trauma does play a role in their genesis.
非寄生虫性脾囊肿（NPSC）的发病机制尚未完全阐明。本多国多中心回顾性研究旨在进一步阐明 NPSC 的起源。
1980 年至 2006 年，在四个欧洲国家的六个儿科外科中心，对 50 例儿童和青少年 NPSC 进行了手术治疗。35 例 NPSC、22 例表皮样囊肿、11 例假性囊肿或创伤后囊肿和 2 例间皮囊肿的初始组织学报告可用。对其进行了额外的重新评估，包括免疫组织化学，以检测囊内表面的细胞角蛋白、癌胚抗原和间皮瘤抗体。特别注意先前脾脏区域创伤的可能性及其在 NPSC 发病机制中的作用。
病理重新评估显示 30 例表皮样囊肿、4 例间皮囊肿和 1 例假性囊肿。免疫组织化学显示，在最初诊断为假性囊肿的 11 例患者中，有 8 例表皮样囊肿和 2 例间皮囊肿。在那些有先前钝性腹部创伤史但超声和计算机断层扫描未证实的患者中，没有假性囊肿。
与普遍观点相反，已经证明 NPSC 是先天性的，没有临床证据表明创伤确实在其发病机制中起作用。
