Grossman Elan J, Inglese Matilde, Bammer Roland
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, NY, USA.
Top Magn Reson Imaging. 2010 Dec;21(6):379-86. doi: 10.1097/RMR.0b013e31823e65b8.
Mild traumatic brain injury (MTBI) is difficult to accurately assess with conventional imaging because such approaches usually fail to detect any evidence of brain damage. Recent studies of MTBI patients using diffusion-weighted imaging and diffusion tensor imaging suggest that these techniques have the potential to help grade tissue damage severity, track its development, and provide prognostic markers for clinical outcome. Although these results are promising and indicate that the forensic diagnosis of MTBI might eventually benefit from the use of diffusion-weighted imaging and diffusion tensor imaging, healthy skepticism and caution should be exercised with regard to interpreting their meaning because there is no consensus about which methods of data analysis to use and very few investigations have been conducted, of which most have been small in sample size and examined patients at only one time point after injury.
轻度创伤性脑损伤（MTBI）很难通过传统成像进行准确评估，因为这些方法通常无法检测到任何脑损伤的证据。最近对MTBI患者使用扩散加权成像和扩散张量成像的研究表明，这些技术有潜力帮助对组织损伤严重程度进行分级，跟踪其发展，并为临床结果提供预后标志物。尽管这些结果很有前景，表明MTBI的法医诊断最终可能会受益于扩散加权成像和扩散张量成像的使用，但在解释其意义时应保持合理的怀疑和谨慎，因为对于使用哪种数据分析方法尚无共识，而且进行的调查很少，其中大多数样本量较小，且仅在受伤后的一个时间点对患者进行检查。
