Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
J Invest Dermatol. 2012 Jan;132(1):7-9. doi: 10.1038/jid.2011.359.
The ligand-activated transcription factor AhR mediates the cutaneous stress response toward a variety of environmental noxae and is therefore currently of interest for modern preventive medicine. In this issue, Tsuji et al. identify the antifungal agent ketoconazole as an inducer of AhR signaling and the Nrf2 antioxidant response in human keratinocytes. Ketoconazole-stimulated nuclear translocation of Nrf2 and its cytoprotective effects against oxidative stress strongly depend on a functional AhR. This newly identified AhR-Nrf2 pathway opens up new opportunities to prevent and treat inflammatory skin diseases.
配体激活转录因子 AhR 介导皮肤对各种环境毒物的应激反应，因此目前是现代预防医学的研究热点。在本期杂志中，Tsuji 等人发现抗真菌药物酮康唑可诱导人角质形成细胞中的 AhR 信号和 Nrf2 抗氧化反应。酮康唑刺激 Nrf2 的核转位及其对氧化应激的细胞保护作用强烈依赖于功能正常的 AhR。这个新发现的 AhR-Nrf2 通路为预防和治疗炎症性皮肤病开辟了新的机会。
