NYGGF4 在胰岛素抵抗中的作用。
Role of NYGGF4 in insulin resistance.
机构信息
Institute of Animal Nutrition, Sichuan Agricultural University, Yaan, 625014, Sichuan, People's Republic of China.
出版信息
Mol Biol Rep. 2012 May;39(5):5367-71. doi: 10.1007/s11033-011-1336-7. Epub 2011 Dec 13.
Insulin resistance is a clinical condition that is characterized by reducing glucose uptake in response to insulin. A major factor in the development of insulin resistance syndrome is obesity. NYGGF4 is a novel gene that is abundantly expressed in the adipose tissue of obese subjects. NYGGF4 induced the secretion of FFAs and TNF-α and caused mitochondrial dysfunction, which may cause insulin resistance. This review will summarize the effect of NYGGF4 on the adipogenesis, glucose uptake and mitochondrial dysfunction in vitro, and the possible mechanism and signal pathway of NYGGF4 for insulin resistance.
胰岛素抵抗是一种临床病症，其特征是对胰岛素的反应降低葡萄糖摄取。胰岛素抵抗综合征发展的一个主要因素是肥胖。NYGGF4 是一种在肥胖患者的脂肪组织中大量表达的新型基因。NYGGF4 诱导 FFAs 和 TNF-α 的分泌，并导致线粒体功能障碍，这可能导致胰岛素抵抗。本综述将总结 NYGGF4 在体外对脂肪生成、葡萄糖摄取和线粒体功能障碍的影响，以及 NYGGF4 导致胰岛素抵抗的可能机制和信号通路。
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