Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.
Mol Biol Rep. 2012 Apr;39(4):5033-42. doi: 10.1007/s11033-011-1300-6. Epub 2011 Dec 9.
We evaluated the association between GSTM1 and GSTT1 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease (COPD) in smokers. A meta-analysis of the published case-control studies was performed. Published literature was retrieved from PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI), with last update in February, 2011. Data were extracted and a fixed- or random-effects model was used to calculate pooled odds ratios with 95% confidence intervals depending on statistical heterogeneity. Fourteen eligible studies, comprising 1,665 COPD cases and 1,614 controls, were included in the meta-analysis. The combined analyses showed that there was a significant difference in GSTM1 genotype distribution between COPD cases and controls among Caucasians, but not among Asians. The combined GSTM1/GSTT1 null genotype conferred a 1.36-fold greater risk for COPD in Asian smokers. The GSTT1 null genotype alone was not associated with enhanced risk for COPD. The GSTM1 null genotype is significantly associated with an increasing susceptibility to COPD in Caucasian smokers, but not in Asian smokers. The GSTM1/GSTT1 null genotype is a significant risk factor for developing COPD in Asian smokers. The GSTT1 null genotype, however, was not associated with COPD.
我们评估了 GSTM1 和 GSTT1 基因多态性与吸烟人群慢性阻塞性肺疾病（COPD）易感性之间的关联。进行了一项已发表病例对照研究的荟萃分析。通过 PubMed、EMBASE 和中国国家知识基础设施（CNKI）检索已发表的文献，检索截止日期为 2011 年 2 月。提取数据并根据统计异质性使用固定或随机效应模型计算合并的优势比及其 95%置信区间。共有 14 项符合条件的研究纳入荟萃分析，包括 1665 例 COPD 病例和 1614 例对照。综合分析显示，白种人中 COPD 病例和对照组的 GSTM1 基因型分布存在显著差异，但亚洲人中不存在。GSTM1/GSTT1 缺失基因型使亚洲吸烟者患 COPD 的风险增加 1.36 倍。单独 GSTT1 缺失基因型与 COPD 风险增加无关。GSTM1 缺失基因型与白种人吸烟者 COPD 易感性增加显著相关，但与亚洲吸烟者无关。GSTM1/GSTT1 缺失基因型是亚洲吸烟者发生 COPD 的显著危险因素。然而，GSTT1 缺失基因型与 COPD 无关。
