Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
Mol Biol Rep. 2012 May;39(5):5187-94. doi: 10.1007/s11033-011-1315-z. Epub 2011 Dec 9.
The aim of this study was to evaluate the association between various cytokine gene polymorphisms and lung cancer (LC) susceptibility. We searched Pubmed, Elsevier Science Direct, China National Knowledge Infrastructure database, Chinese Biomedical database, Google scholar. Totally, 20 studies involving 6,467 cases and 8,320 controls were included in the meta-analysis. The effects of eight polymorphisms, i.e. TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C, IL-10 1082G/A, IL-10 819C/T, and IL-10 592C/A were evaluated. The combined odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate the strength of the association in a fixed or random effect model. Heterogeneity and publication bias were also assessed. We found a significant association between IL-10 polymorphism and LC. For IL-10 1082G/A, the overall ORs (95% CI) of the G versus A, GG versus AA, and GG/GA versus AA were 2.35 (1.16-4.76), 2.07 (1.16-3.70) and 3.17 (1.31-7.68), respectively. For IL-10 819C/T, the pooled ORs (95% CI) of the C versus T and CC versus TT were 1.27 (1.01-1.58) and 2.27 (1.32-3.89). For IL-10 592C/A, the comparison of subjects in the CC or CC/CA genotype versus AA homozygotes showed significant results (OR = 2.00, 95% CI: 1.24-3.23; OR = 1.80, 95% CI: 1.28-2.54). But, other gene polymorphisms did not reach statistical associations. IL-10 1082G/A, 819C/T and 592C/A polymorphisms might be risk factors for LC. TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC. Due to the limitation of the number of the studies, we should take the conclusion with caution. While, further studies are necessary for more precise association.
本研究旨在评估各种细胞因子基因多态性与肺癌（LC）易感性之间的关联。我们检索了 Pubmed、爱思唯尔科学直接、中国国家知识基础设施数据库、中国生物医学数据库和谷歌学术。共有 20 项研究，涉及 6467 例病例和 8320 例对照，纳入了荟萃分析。评估了 8 种多态性，即 TNF-α 308G/A、IL-6 174G/C、IL-1β 31T/C、IL-1β 511C/T、COX-2 8473T/C、IL-10 1082G/A、IL-10 819C/T 和 IL-10 592C/A 的影响。采用固定或随机效应模型计算合并优势比（OR）及其 95%置信区间（95%CI），以评估关联的强度。还评估了异质性和发表偏倚。我们发现 IL-10 多态性与 LC 之间存在显著关联。对于 IL-10 1082G/A，G 对 A、GG 对 AA 和 GG/GA 对 AA 的总体 OR（95%CI）分别为 2.35（1.16-4.76）、2.07（1.16-3.70）和 3.17（1.31-7.68）。对于 IL-10 819C/T，C 对 T 和 CC 对 TT 的合并 OR（95%CI）分别为 1.27（1.01-1.58）和 2.27（1.32-3.89）。对于 IL-10 592C/A，与 AA 纯合子相比，CC 或 CC/CA 基因型个体的比较显示出显著结果（OR=2.00，95%CI：1.24-3.23；OR=1.80，95%CI：1.28-2.54）。但是，其他基因多态性没有达到统计学关联。IL-10 1082G/A、819C/T 和 592C/A 多态性可能是 LC 的危险因素。TNF-α 308G/A、IL-6 174G/C、IL-1β 31T/C、IL-1β 511C/T、COX-2 8473T/C 多态性未发现与 LC 风险相关。由于研究数量的限制，我们应该谨慎得出结论。然而，需要进一步的研究以获得更精确的关联。
