Jafari-Nedooshan Jamal, Moghimi Mansour, Zare Mohammad, Heiranizadeh Naeimeh, Morovati-Sharifabad Majid, Akbarian-Bafghi Mohamad Javad, Jarahzadeh Mohammad Hossein, Neamatzadeh Hossein
Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
Asian Pac J Cancer Prev. 2019 Jul 1;20(7):1951-1957. doi: 10.31557/APJCP.2019.20.7.1951.
Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10) gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10 gene with susceptibility to lung cancer. Methods: a comprehensive search of PubMed, EMBASE, and CNKI databases was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association. Results: A total number of 19 case-control studies with 4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR= 1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However, there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk. Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer among Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism might be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G polymorphisms are not significantly associated with increased risk of lung cancer.
流行病学研究表明，白细胞介素-10（IL-10）基因启动子区域多态性可能与肺癌风险增加有关。然而，这些研究结果存在争议。因此，进行了一项综合荟萃分析，以评估IL-10基因启动子区域多态性与肺癌易感性之间的关联。方法：全面检索了PubMed、EMBASE和CNKI数据库，以查找截至2018年9月15日的所有符合条件的研究。采用合并比值比（OR）和95%置信区间（CI）来评估这种关联的强度。结果：共纳入19项病例对照研究，包括4084例病例和6131例对照。总体荟萃分析结果显示，在四种遗传模型下，-592A>C多态性与肺癌风险显著相关，即等位基因（CT与TT：OR = 1.17，95% CI 1.01 - 1.35，p = 0.02）、纯合子（CC与AA：OR = 1.64，95% CI 1.29 - 2.02，p≤0.001）、杂合子（CA与AA：OR = 1.26，95% CI 1.06 - 1.50，p≤0.001）和显性模型（CC + CA与AA：OR = 1.31，95% CI 1.11 - 1.54，p = 0.001）。然而，IL-10的-819T>C和-1082A>G多态性与肺癌风险之间无显著关联。同样，按种族进行的亚组分析发现，IL-10 -592A>C与亚洲人和白种人的肺癌之间存在显著关联。结论：我们的荟萃分析表明，IL-10 -592A>C多态性可能是肺癌的危险因素，尤其是在亚洲人和白种人中。相比之下，IL-10 -819T>C和-1082A>G多态性与肺癌风险增加无显著关联。
