Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Chromosome Res. 2012 Jan;20(1):153-62. doi: 10.1007/s10577-011-9256-x.
Even though the mammalian sex-determining gene Sry has been intensively studied for the two decades since its discovery, the regions outside the conserved HMG box DNA-binding domain have received less attention due to a lack of sequence conservation and of obvious structural/functional motifs. Here, we summarize the available evidence for function beyond the HMG box, identify the known and postulated biochemical functions of the non-HMG-box domains in sex determination, and present possible explanations for the puzzling diversity of these non-HMG-box domains.
尽管哺乳动物性别决定基因 Sry 自发现以来已经被研究了二十年，但由于缺乏序列保守性和明显的结构/功能基序，保守 HMG 盒 DNA 结合域之外的区域受到的关注较少。在这里，我们总结了 HMG 盒以外功能的现有证据，确定了性别决定中非 HMG 盒结构域的已知和假设的生化功能，并对这些非 HMG 盒结构域令人困惑的多样性提出了可能的解释。
