Developmental Endocrinology Research Group, University of Glasgow, Glasgow, United Kingdom.
MRC Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Front Endocrinol (Lausanne). 2022 Jul 14;13:919670. doi: 10.3389/fendo.2022.919670. eCollection 2022.
The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8 week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD.
睾丸中的支持细胞在性腺发育过程中起着至关重要的作用，除此之外，还支持随后的生殖细胞存活和精子发生。抗缪勒管激素（AMH）是转化生长因子-β 超家族的成员，由胎儿 8 周龄时未成熟的支持细胞分泌。抑制素 B 是一种糖蛋白，由胎儿发育早期的支持细胞产生。在性别发育障碍（DSD）患者中，这些激素可能有助于确定睾丸组织的存在和精子发生的潜力。然而，在 DSD 情况下，胎儿支持细胞的发育和功能通常会失调，并且在这些个体的整个生命过程中可能会检测到支持细胞激素的产生改变。因此，本综述将考虑 AMH 和抑制素 B 在 DSD 个体中的作用。
