Schiff E, Barkai G, Ben-Baruch G, Mashiach S
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel.
Obstet Gynecol. 1990 Nov;76(5 Pt 1):742-4. doi: 10.1097/00006250-199011000-00002.
The effect of low doses of aspirin on women with mild pregnancy-induced hypertension was investigated by means of a prospective, randomized, double-blind trial. Forty-seven women hospitalized at 30-36 weeks' gestation because of mild pregnancy-induced hypertension were treated by a daily dose of either 100 mg aspirin or placebo. The mean blood pressure values, rates of development of severe preeclampsia, gestational ages at delivery, newborn weights, and 5-minute Apgar scores were similar in the aspirin-treated and the placebo-treated groups. We conclude that low-dose aspirin is not curative but is essentially a preventive treatment which, in order to be effective, should be started weeks before clinical signs of preeclampsia are present.
通过一项前瞻性、随机、双盲试验，研究了低剂量阿司匹林对轻度妊娠高血压综合征妇女的影响。47名因轻度妊娠高血压综合征于妊娠30 - 36周住院的妇女，分别接受每日100毫克阿司匹林或安慰剂治疗。阿司匹林治疗组和安慰剂治疗组的平均血压值、重度子痫前期的发生率、分娩时的孕周、新生儿体重和5分钟阿氏评分相似。我们得出结论，低剂量阿司匹林并无治疗作用，本质上是一种预防性治疗，要想有效，应在子痫前期临床症状出现前数周开始使用。
