Fraser Stuart T, Midwinter Robyn G, Berger Birgit S, Stocker Roland
Laboratory for Blood Cell Development, Disciplines of Physiology, Anatomy and Histology, School of Medical Sciences and Bosch Institute, University of Sydney, Medical Foundation Building, 92-94 Parramatta Road, Camperdown, NSW 2050, Australia.
Adv Hematol. 2011;2011:473709. doi: 10.1155/2011/473709. Epub 2011 Nov 20.
The first mature cells to arise in the developing mammalian embryo belong to the erythroid lineage. This highlights the immediacy of the need for red blood cells during embryogenesis and for survival. Linked with this pressure is the necessity of the embryo to obtain and transport iron, synthesize hemoglobin, and then dispose of the potentially toxic heme via the stress-induced protein heme oxygenase-1 (HO-1, encoded by Hmox1 in the mouse). Null mutation of Hmox1 results in significant embryonic mortality as well as anemia and defective iron recycling. Here, we discuss the interrelated nature of this critical enzyme with iron trafficking, erythroid cell function, and embryonic survival.
在发育中的哺乳动物胚胎中最早出现的成熟细胞属于红细胞谱系。这凸显了胚胎发育过程中对红细胞以及生存所需红细胞的迫切需求。与这种压力相关的是胚胎获取和运输铁、合成血红蛋白，然后通过应激诱导蛋白血红素加氧酶-1（HO-1，在小鼠中由Hmox1编码）处理潜在有毒血红素的必要性。Hmox1的无效突变会导致显著的胚胎死亡以及贫血和铁循环缺陷。在此，我们讨论这种关键酶与铁转运、红细胞功能和胚胎存活之间的相互关系。
